Mood Disorders Program, Department of Psychiatry, University Hospitals Cleveland Medical Center, Cleveland, OH, United States of America; Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.
Mood Disorders Program, Department of Psychiatry, University Hospitals Cleveland Medical Center, Cleveland, OH, United States of America; Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.
J Affect Disord. 2024 Oct 1;362:493-501. doi: 10.1016/j.jad.2024.07.016. Epub 2024 Jul 14.
To study the prevalence of fatigue and factors associated with fatigue in patients with major depressive disorder (MDD) or bipolar disorder (BD).
Two hundred fifty-three outpatients with MDD or BD at the initial assessment were used to study the prevalence of fatigue and relationship between fatigue and other clinical correlates. The severity of fatigue was measured with Iowa Fatigue Scale (IFS), and depression and anxiety symptom-severity were measured with the QIDS-16-SR (the 16-item Quick Inventory of Depressive Symptomatology - Self-Report) and Zung-SAS (Zung Self-Rating Anxiety Scale). Correlation between IFS and QIDS-16-SR total scores, QIDS-16-SR item scores or Zung-SAS total scores, and independent factors associated with fatigue was assessed with simple or multiple linear regression analysis.
Overall, 28.4 % of MDD and 29.8 % of BD patients did not have fatigue, but 41.2 % of MDD and 45.0 % of BD patients had fatigue, and 30.4 % of MDD and 25.2 % of BD patients had severe fatigue. Depression/anxiety severity was significantly correlated with fatigue. However, after controlling current psychiatric comorbidities, demographics, some social factors, and psychotropic use, only QIDS-16-SR scores were still significantly and positively correlated with IFS scores in both MDD and BD. Differential correlations between IFS scores and item scores of QIDS-16-SR in MDD and BD were observed.
Cross-sectional.
In this outpatient sample, fatigue was highly prevalent in patients with MDD or BD. The independent association of depressive severity with the severity of fatigue highlights the importance of complete resolution of depressive symptoms in treating MDD and BD.
研究重性抑郁障碍（MDD）或双相障碍（BD）患者疲劳的发生率及与疲劳相关的因素。
采用初始评估时的 253 例 MDD 或 BD 门诊患者，研究疲劳的发生率以及疲劳与其他临床相关性之间的关系。采用爱荷华疲劳量表（IFS）评估疲劳严重程度，采用 QIDS-16-SR（16 项简易抑郁症状自评量表）和 Zung-SAS（Zung 焦虑自评量表）评估抑郁和焦虑症状严重程度。采用简单或多元线性回归分析评估 IFS 与 QIDS-16-SR 总分、QIDS-16-SR 各条目得分或 Zung-SAS 总分之间的相关性，以及与疲劳相关的独立因素。
总体而言，28.4%的 MDD 患者和 29.8%的 BD 患者无疲劳，但 41.2%的 MDD 患者和 45.0%的 BD 患者有疲劳，30.4%的 MDD 患者和 25.2%的 BD 患者有严重疲劳。抑郁/焦虑严重程度与疲劳显著相关。然而，在控制当前精神共病、人口统计学、一些社会因素和精神药物使用后，仅 QIDS-16-SR 评分在 MDD 和 BD 中仍与 IFS 评分显著正相关。在 MDD 和 BD 中观察到 IFS 评分与 QIDS-16-SR 各条目得分之间的差异相关性。
横断面研究。
在该门诊患者样本中，MDD 或 BD 患者的疲劳发生率较高。抑郁严重程度与疲劳严重程度的独立相关性突出了在治疗 MDD 和 BD 时完全缓解抑郁症状的重要性。
