Vallenas C, Hernandez H, Kay B, Black R, Gotuzzo E
Pediatr Infect Dis. 1985 Sep-Oct;4(5):496-8. doi: 10.1097/00006454-198509000-00011.
The relative efficacy of cultures made from duodenal contents (obtained by string capsules), bone marrow, blood and rectal swab was compared in 118 pediatric patients, 2 to 13 years old with suspected typhoid fever. Only 47% of children 2 to 6 years old tolerated the string device, as compared with 89% in children 7 to 13 years old (P less than 0.05). The four culture techniques were performed and at least one was positive for Salmonella typhi in 43 patients. Bone marrow cultures were positive in 84% of the confirmed cases, a sensitivity significantly greater than for duodenal contents (42%), blood (44%) and stool (65%) cultures. Higher recovery rates for blood cultures were found during the first week of illness than later (70 vs. 22%). Bone marrow cultures remain the most effective method for the recovery of S. typhi. Stool cultures appear to be more effective in children than in adults. Duodenal contents cultures offer little advantage in young (2 to 6 years old) children.
对118名2至13岁疑似伤寒热的儿科患者，比较了由十二指肠内容物（通过线囊获取）、骨髓、血液和直肠拭子培养物的相对效力。2至6岁儿童中只有47%能耐受线囊装置，而7至13岁儿童中这一比例为89%（P<0.05）。进行了四种培养技术，43例患者中至少有一种对伤寒沙门菌呈阳性。在确诊病例中，骨髓培养阳性率为84%，其敏感性显著高于十二指肠内容物培养（42%）、血液培养（44%）和粪便培养（65%）。疾病第一周血液培养的回收率高于后期（70%对22%）。骨髓培养仍然是分离伤寒沙门菌最有效的方法。粪便培养在儿童中似乎比在成人中更有效。十二指肠内容物培养对年幼（2至6岁）儿童几乎没有优势。
