Ukponmwan O E, vd Poel-Heisterkamp A L, Dzoljic M R
Pharmacol Biochem Behav. 1985 Sep;23(3):385-9. doi: 10.1016/0091-3057(85)90010-3.
Intraventricular administration of enkephalinase inhibitor, phosphoramidon (1 X 10(-8)-5.6 X 10(-7) moles ICV) induced a behavioural syndrome consisting of excessive grooming with the body scratching as the most prominent symptom and wet-dog-shakes (WDS). The frequency of the phosphoramidon-induced WDS and body scratching were decreased by the pretreatment with the opiate receptor blocking agent, naltrexone (2.9 X 10(-6) moles/kg IP). Both the phosphoramidon-induced WDS in naive rats and naloxone-precipitated withdrawal WDS were decreased in REM sleep deprived rats compared with animals allowed normal sleep (control and stress groups). The results are discussed in light of a possible functional insufficiency of endorphinergic system during REMSD. It has been suggested that this insufficiency might be a background to the increased neuronal excitability during REMSD.
脑室内注射脑啡肽酶抑制剂磷酰胺素（1×10⁻⁸ - 5.6×10⁻⁷摩尔，脑室内注射）诱发了一种行为综合征，其最突出的症状是身体抓挠过度梳理毛发以及湿狗样抖动（WDS）。阿片受体阻断剂纳曲酮（2.9×10⁻⁶摩尔/千克，腹腔注射）预处理可降低磷酰胺素诱发的WDS和身体抓挠的频率。与正常睡眠的动物（对照组和应激组）相比，快速眼动睡眠剥夺大鼠中，磷酰胺素诱发的WDS以及纳洛酮诱发的戒断性WDS均减少。根据快速眼动睡眠剥夺期间内源性阿片系统可能存在的功能不足对结果进行了讨论。有人提出，这种不足可能是快速眼动睡眠剥夺期间神经元兴奋性增加的一个背景因素。
