Ukponmwan O E, Dzoljic M R
Psychopharmacology (Berl). 1984;83(3):229-32. doi: 10.1007/BF00464786.
In order to elucidate the relationship between REM sleep and the enkephalinergic system, the effects of REM sleep deprivation (REMSD), stress and the enkephalinase inhibitor phosphoramidon on handling-induced convulsions were studied in mice. REMSD, stress and phosphoramidon (25-500 micrograms icv) increased the frequency of handling-induced convulsions (HIC) in normal mice. However, only in the last two groups were HIC antagonized by naloxone (1 mg/kg IP). In REMSD mice, phosphoramidon decreased the frequency of HIC, this effect being abolished by naloxone. The increase of neuronal excitability during REMSD is suggested to be associated with an insufficiency of the enkephalinergic system.
为了阐明快速眼动睡眠（REM睡眠）与脑啡肽能系统之间的关系，研究了快速眼动睡眠剥夺（REMSD）、应激以及脑啡肽酶抑制剂磷酰胺素对小鼠处理诱导惊厥的影响。REMSD、应激和磷酰胺素（脑室内注射25 - 500微克）增加了正常小鼠处理诱导惊厥（HIC）的频率。然而，仅在后两组中，纳洛酮（腹腔注射1毫克/千克）可拮抗HIC。在REMSD小鼠中，磷酰胺素降低了HIC的频率，该效应被纳洛酮消除。提示REMSD期间神经元兴奋性的增加与脑啡肽能系统功能不足有关。
