Ukponmwan O E, Rupreht J, Dzoljic M R
Gen Pharmacol. 1984;15(3):255-8. doi: 10.1016/0306-3623(84)90170-8.
Rats treated with phosphoramidon (an enkephalinase-inhibitor 250 micrograms, i.c.v.), morphine (20 micrograms i.c.v.) or subjected to cold-water-swim (CWS, animals forced to swim in water at 5 degrees C for 5 min) showed consistent analgesia. The antinociceptive effect of phosphoramidon, morphine and CWS was antagonised by REM sleep deprivation (REMSD). It is suggested that normal duration of REM sleep is of importance for the anti-nociceptive activity of endogenous and exogenous opiates.
用磷酰胺（一种脑啡肽酶抑制剂，250微克，脑室内注射）、吗啡（20微克，脑室内注射）处理的大鼠，或进行冷水游泳（CWS，动物被迫在5摄氏度的水中游泳5分钟）的大鼠均表现出持续的镇痛作用。磷酰胺、吗啡和CWS的抗伤害感受作用被快速眼动睡眠剥夺（REMSD）拮抗。这表明正常时长的快速眼动睡眠对内源性和外源性阿片类药物的抗伤害感受活性很重要。
