与印度尼西亚感染患者的乙型肝炎和丙型肝炎相关因素及其知识和态度：一项多中心观察性研究。

Factors Associated with Hepatitis B and Hepatitis C among Infected Patients in Indonesia and Their Knowledge and Attitude: A Multicenter Observational Study.

机构信息

Division of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

出版信息

Acta Med Indones. 2024 Apr;56(2):155-167.

PMID:39010774

Abstract

BACKGROUND

Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infections are global health problems, including in Indonesia. The purpose of this study was to assess the knowledge and attitudes about HBV and HCV infection among infected patients in Indonesia.

METHODS

This cross-sectional study used a questionnaire survey. The questionnaire was adapted and translated into Indonesian language, and trialed with 27 HBV and 27 HCV patients. The final validated questionnaire was later used in the target population. Patients diagnosed with Hepatitis B or Hepatitis C were included. The patients were enrolled from November 2019 until February 2020 in sixteen multicenter locations. Multivariate analysis with logistic regression was conducted to determine the factors that are associated with the knowledge and attitude among HBV and HCV patients toward their illness.

RESULTS

A total of 931 HBV patients and 254 HCV patients were included in this survey. The proportion of infected patients with adequate knowledge of Hepatitis B and Hepatitis C was 72.1% and 53.9%, respectively. Positive attitudes about Hepatitis B and Hepatitis C were 28.5% and 41.3%, respectively. Multivariate analysis revealed that higher education level, higher income level, diagnosis duration of more than 5 years, and receiving of antiviral therapy were independent factors associated with adequate knowledge about Hepatitis B among HBV patients. Among HCV patients, independent factors associated with adequate knowledge about Hepatitis C were being married, higher education level, higher income level, and receiving antiviral therapy. Moreover, older age and receiving of antiviral therapy were independent factors associated with positive attitudes towards Hepatitis B among HBV patients. However, only higher education level was found to be an independent factor associated with positive attitudes towards Hepatitis C among HCV patients.

CONCLUSION

The knowledge and attitude of patients regarding HBV and HCV were quite low among infected patients in Indonesia.

摘要

背景

乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染是全球性健康问题，包括印度尼西亚。本研究旨在评估印度尼西亚感染患者对 HBV 和 HCV 感染的知识和态度。

方法

本横断面研究采用问卷调查。问卷经过改编并翻译成印度尼西亚语，并在 27 名 HBV 和 27 名 HCV 患者中进行了试验。经过验证的最终问卷随后用于目标人群。纳入诊断为乙型肝炎或丙型肝炎的患者。2019 年 11 月至 2020 年 2 月，在 16 个多中心地点招募了患者。采用逻辑回归进行多变量分析，以确定与 HBV 和 HCV 患者对疾病的知识和态度相关的因素。

结果

本调查共纳入 931 名 HBV 患者和 254 名 HCV 患者。乙型肝炎和丙型肝炎知识充足的感染患者比例分别为 72.1%和 53.9%。乙型肝炎和丙型肝炎的积极态度比例分别为 28.5%和 41.3%。多变量分析显示，较高的教育水平、较高的收入水平、诊断时间超过 5 年以及接受抗病毒治疗是 HBV 患者对乙型肝炎有充足知识的独立相关因素。在 HCV 患者中，对丙型肝炎有充足知识的独立相关因素是已婚、较高的教育水平、较高的收入水平和接受抗病毒治疗。此外，年龄较大和接受抗病毒治疗是 HBV 患者对乙型肝炎有积极态度的独立相关因素。然而，只有较高的教育水平是 HCV 患者对丙型肝炎有积极态度的独立相关因素。