Bampidis Vasileios, Azimonti Giovanna, Bastos Maria de Lourdes, Christensen Henrik, Durjava Mojca, Dusemund Birgit, Kouba Maryline, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Ramos Fernando, Villa Roberto Edoardo, Woutersen Ruud, Brantom Paul, Glandorf Boet, Anguita Montserrat, Innocenti Matteo Lorenzo, Tarrés-Call Jordi, Pettenati Elisa
EFSA J. 2024 Jul 15;22(7):e8852. doi: 10.2903/j.efsa.2024.8852. eCollection 2024 Jul.
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of the feed additive consisting of endo-1,4-beta-xylanase (produced with MUCL 49755) and endo-1,3(4)-beta-glucanase (produced with MUCL 49754) (AveMix® XG 10/AveMix® XG 10 L) as a zootechnical feed additive for weaned and suckling piglets. The additive is already authorised for use in weaned piglets. This scientific opinion concerns the request for the renewal of the authorisation of the additive for weaned piglets and the extension of use to suckling piglets. The applicant declared a change in the carrier material used in AveMix® XG 10 from soybean meal to calcium carbonate + wheat flour or calcium carbonate + sepiolite. The applicant provided evidence that the additive AveMix® XG 10 with calcium carbonate + wheat flour and AveMix® XG 10 L comply with the conditions of the authorisation. The EFSA Panel on Additives and Products or Substances used in Animal FEED (FEEDAP) noted that no data were submitted to support compliance of the formulation of AveMix® XG 10 with calcium carbonate + sepiolite with the conditions of the authorisation. The FEEDAP Panel concluded that both formulations of the additive (powder and liquid) remain safe for the target species, consumers and the environment, and that the extension of use to suckling piglets would not affect these conclusions. AveMix® XG 10 formulated with calcium carbonate + sepiolite and AveMix® XG 10 L are not irritant to skin and eyes. No conclusions on the irritation potential of AveMix® XG 10 formulated with calcium carbonate + wheat flour could be drawn. The additive in all its formulations is considered a respiratory and skin sensitiser. There was no need for assessing the efficacy of the additive in the context of the renewal of the authorisation for weaned piglets. The Panel concluded that the additive is efficacious in suckling piglets at 4000 XU and 900 BGU/kg complete feed.
应欧盟委员会的要求，欧洲食品安全局（EFSA）被要求就一种饲料添加剂的安全性和有效性提供科学意见，该添加剂由内切 - 1,4 - β - 木聚糖酶（由MUCL 49755生产）和内切 - 1,3(4) - β - 葡聚糖酶（由MUCL 49754生产）组成（AveMix® XG 10/AveMix® XG 10 L），用作断奶仔猪和哺乳仔猪的动物营养饲料添加剂。该添加剂已被批准用于断奶仔猪。本科学意见涉及该添加剂用于断奶仔猪授权续期以及将使用范围扩展至哺乳仔猪的申请。申请人宣称AveMix® XG 10中使用的载体材料已从豆粕变更为碳酸钙 + 小麦粉或碳酸钙 + 海泡石。申请人提供证据表明含有碳酸钙 + 小麦粉的添加剂AveMix® XG 10以及AveMix® XG 10 L符合授权条件。欧洲食品安全局动物饲料添加剂和产品或物质专家小组（FEEDAP）指出，未提交数据以支持含有碳酸钙 + 海泡石的AveMix® XG 10配方符合授权条件。FEEDAP小组得出结论，该添加剂的两种配方（粉剂和液体）对目标物种、消费者和环境仍然是安全的，并且将使用范围扩展至哺乳仔猪不会影响这些结论。含有碳酸钙 + 海泡石的AveMix® XG 10和AveMix® XG 10 L对皮肤和眼睛无刺激性。对于含有碳酸钙 + 小麦粉的AveMix® XG 10的刺激潜力无法得出结论。该添加剂的所有配方均被视为呼吸道和皮肤致敏剂。在断奶仔猪授权续期的背景下，无需评估该添加剂的有效性。小组得出结论，该添加剂在哺乳仔猪的全价饲料中添加量为4000 XU和900 BGU/kg时具有功效。
