Department of Pharmacy, Guangyuan Central Hospital, Guangyuan, Sichuan, China.
Department of Pharmacy, Ezhou Central Hospital, Ezhou, Hubei, China.
Front Immunol. 2024 Jul 1;15:1378990. doi: 10.3389/fimmu.2024.1378990. eCollection 2024.
Pyroptosis, a form of caspase-1-dependent cell death, also known as inflammation-dependent death, plays a crucial role in diseases such as stroke, heart disease, or tumors. Since its elucidation, pyroptosis has attracted widespread attention from various sectors. Reactive oxygen species (ROS) can regulate numerous cellular signaling pathways. Through further research on ROS and pyroptosis, the level of ROS has been revealed to be pivotal for the occurrence of pyroptosis, establishing a close relationship between the two. This review primarily focuses on the molecular mechanisms of ROS and pyroptosis in tumors and inflammatory diseases, exploring key proteins that may serve as drug targets linking ROS and pyroptosis and emerging fields targeting pyroptosis. Additionally, the potential future development of compounds and proteins that influence ROS-regulated cell pyroptosis is anticipated, aiming to provide insights for the development of anti-tumor and anti-inflammatory drugs.
细胞焦亡，一种依赖半胱天冬酶-1 的细胞死亡形式，也称为炎症依赖性死亡，在中风、心脏病或肿瘤等疾病中起着关键作用。自其阐明以来，细胞焦亡受到了各个领域的广泛关注。活性氧（ROS）可以调节许多细胞信号通路。通过进一步研究 ROS 和细胞焦亡，ROS 的水平被揭示对细胞焦亡的发生至关重要，两者之间建立了密切的关系。本综述主要关注 ROS 和细胞焦亡在肿瘤和炎症性疾病中的分子机制，探索可能作为连接 ROS 和细胞焦亡的药物靶点的关键蛋白，以及针对细胞焦亡的新兴领域。此外，预计影响 ROS 调节的细胞焦亡的化合物和蛋白的潜在未来发展，旨在为抗肿瘤和抗炎药物的开发提供思路。
