Cleri Nathaniel A, Zhang Jason, Singh Gurinder, Mikell Charles B, Pendleton Courtney
Neurosurgery, Stony Brook University, Stony Brook, USA.
Internal Medicine, Mount Sinai West, New York, USA.
Cureus. 2024 Jun 15;16(6):e62438. doi: 10.7759/cureus.62438. eCollection 2024 Jun.
Anabolic androgenic steroids (AAS) are relatively cheap and accessible medications, commonly used by athletes and bodybuilders for performance enhancement and muscle growth stimulation. AAS usage has been associated with musculoskeletal injuries, such as tendon and ligament ruptures, and numerous other detrimental health effects. Despite these risks, individuals continue to self-administer these drugs in supraphysiologic doses. Here, we present a case of a male bodybuilder with chronic AAS use who developed a spinal thoracic intervertebral disc herniation requiring decompression and fusion. We use this case to highlight a severe potential risk associated with chronic AAS abuse and review the current literature on the biochemical, physical, and physiologic mechanisms linking chronic AAS use, weight-bearing exercise, and the risk of musculoskeletal injuries such as intervertebral disc herniations.
合成代谢雄激素类固醇（AAS）是相对便宜且容易获得的药物，运动员和健美运动员常用其来提高成绩和刺激肌肉生长。使用AAS与肌肉骨骼损伤有关，如肌腱和韧带断裂，以及许多其他有害的健康影响。尽管存在这些风险，人们仍继续超生理剂量自行服用这些药物。在此，我们报告一例长期使用AAS的男性健美运动员病例，该患者发生了胸椎椎间盘突出症，需要进行减压和融合手术。我们利用该病例强调长期滥用AAS的严重潜在风险，并回顾当前关于慢性AAS使用、负重运动以及诸如椎间盘突出症等肌肉骨骼损伤风险之间联系的生化、物理和生理机制的文献。
