Chen Jiamei, Wang Jin, Deng Ziwei, Li Yongzhong, Zhou Jianliang
Department of Infectious Diseases, Hunan Medical College General Hospital, Huaihua, Hunan Province, People's Republic of China.
Department of Clinical Pharmacy Group, Hunan Medical College General Hospital, Huaihua, Hunan Province, People's Republic of China.
Infect Drug Resist. 2024 Jul 11;17:2913-2921. doi: 10.2147/IDR.S453900. eCollection 2024.
We aimed to describe the difference between pneumonia group and non bacterial pneumonia group in community acquired pneumonia in this single-center clinical study.
We collected the data of 35 patients with pneumonia cases and 46 patients with non bacterial pneumonia cases diagnosed with metagenomic next-generation sequencing assays from February 2019 to December 2021 in Huaihua First People's Hospital in China.
In the pneumonia group, 35 patients (100%) had a chance of exposure to poultry or birds, and their body temperature was greater than or equal to 39.0°C. The other common symptoms were a slow pulse (68.6%), cough (65.7%), expectoration (54.3%), chills (51.4%) and a shortness of breath (37.1%). Laboratory tests showed that >90% of the cases had markedly elevated infection indicators, and 97.1% of the cases had markedly declined calcium. The most common imaging finding was patchy shadows (94.3%), pleural effusion (68.6%), bilateral in 54.3% (n = 19) and unilateral in 45.7% (n = 16) participants, and 51.4% (n = 18) of cases met the criteria for severe pneumonia. In the non bacterial pneumonia group, 18 patients (39.1%) had a chance of exposure to poultry or birds, and 11 patients (23.9%) body temperature was greater than or equal to 39.0°C. Laboratory tests showed that >67% of cases had a mildly elevated infection indicators, and mildly declined serum albumin.
The following characteristics are more likely to help distinguish pneumonia from non bacterial pneumonia. Including had a chance of exposure to poultry or birds, high fever, exhibit chills, expectoration, relatively slow pulse, and progress into severe pneumonia. Percentage of neutrophils, C-reactive protein, procalcitonin, lactate dehydrogenase, and myoglobin levels are higher. Blood calcium and corrected calcium are lower. Chest CT showed pleural effusion, pericardial effusion, and mediastinal lymphadenopathy.
在这项单中心临床研究中，我们旨在描述社区获得性肺炎中肺炎组与非细菌性肺炎组之间的差异。
我们收集了2019年2月至2021年12月在中国怀化市第一人民医院通过宏基因组下一代测序检测确诊的35例肺炎患者和46例非细菌性肺炎患者的数据。
在肺炎组中，35例患者（100%）有接触家禽或鸟类的机会，且体温大于或等于39.0°C。其他常见症状为脉搏缓慢（68.6%）、咳嗽（65.7%）、咳痰（54.3%）、寒战（51.4%）和呼吸急促（37.1%）。实验室检查显示，>90%的病例感染指标明显升高，97.1%的病例血钙明显下降。最常见的影像学表现为斑片状阴影（94.3%）、胸腔积液（68.6%），双侧胸腔积液者占54.3%（n = 19），单侧胸腔积液者占45.7%（n = 16），51.4%（n = 18）的病例符合重症肺炎标准。在非细菌性肺炎组中，18例患者（39.1%）有接触家禽或鸟类的机会，11例患者（23.9%）体温大于或等于39.0°C。实验室检查显示，>67%的病例感染指标轻度升高，血清白蛋白轻度下降。
以下特征更有助于区分肺炎与非细菌性肺炎。包括有接触家禽或鸟类的机会、高热、出现寒战、咳痰、脉搏相对缓慢以及进展为重症肺炎。中性粒细胞百分比、C反应蛋白、降钙素原、乳酸脱氢酶和肌红蛋白水平较高。血钙和校正血钙较低。胸部CT显示胸腔积液、心包积液和纵隔淋巴结肿大。
