Bozorgzade Saeid-Ali, Kalantar-Khandani Shahram, Amiri Rezvan, Dehesh Tania, Karegar-Borzi Hossein
Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Department of Traditional Medicine, Faculty of Persian Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Iran J Parasitol. 2024 Apr-Jun;19(2):203-213. doi: 10.18502/ijpa.v19i2.15856.
Leishmaniasis is highly prevalent worldwide, and while conventional medicine offers numerous treatment methods for cutaneous leishmaniasis, Iranian traditional medicine suggests various remedies. We aimed to evaluate the efficacy of an herbal combination containing leaves, resin, and seeds in patients with zoonotic cutaneous leishmaniasis.
This study was conducted at the Leishmaniasis Department of Chabahar Health Center in southeastern Iran in 2021. It was a double-blinded randomized clinical trial involving 68 patients enrolled after clinical diagnosis, examination of smear samples using Giemsa staining, and PCR confirmation. The volunteers were randomly divided into intervention and control groups. Both groups received 'Glucantime ® as the primary medication weekly until complete healing or up to 12 weeks. Glucantime ® was administered intralesionally at a dosage of 0.1 cc on the wound's margin, with repeat injections at 1 cm intervals along the wound edge when necessary. In addition to the main drug, the intervention group received the herbal product topically twice daily until wound healing or for up to 4 weeks, while the control group received a placebo in the same manner.
82.35% of patients in the intervention group and 20.58% in the control group achieved complete healing within four weeks. There was a significant difference between the two groups ( < 0.001).
The herbal product demonstrated effectiveness in treating patients with zoonotic cutaneous leishmaniasis.
利什曼病在全球范围内高度流行，虽然传统医学为皮肤利什曼病提供了多种治疗方法，但伊朗传统医学也提出了各种疗法。我们旨在评估一种含有[植物名称1]叶、[植物名称2]树脂和[植物名称3]种子的草药组合对动物源性皮肤利什曼病患者的疗效。
本研究于2021年在伊朗东南部恰巴哈尔健康中心的利什曼病科进行。这是一项双盲随机临床试验，68名患者在临床诊断、吉姆萨染色涂片样本检查和PCR确认后入组。志愿者被随机分为干预组和对照组。两组均每周接受一次“葡糖胺锑钠®”作为主要药物，直至完全愈合或长达12周。葡糖胺锑钠®以0.1毫升的剂量在伤口边缘进行皮损内注射，必要时沿伤口边缘每隔1厘米重复注射。除主要药物外，干预组每天局部使用该草药产品两次，直至伤口愈合或长达4周，而对照组则以相同方式接受安慰剂。
干预组82.35%的患者和对照组20.58%的患者在四周内实现了完全愈合。两组之间存在显著差异（<0.001）。
该草药产品在治疗动物源性皮肤利什曼病患者方面显示出有效性。
