Trusova Valeriya, Karnaukhov Ivan, Zelinsky Andrey, Borts Borys, Ushakov Igor, Sidenko Larysa, Gorbenko Galyna
Department of Medical Physics & Biomedical Nanotechnologies, V.N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv 61022, Ukraine.
National Science Center "Kharkov Institute of Physics and Technology", Kharkiv, Ukraine.
Nanomedicine (Lond). 2024 Jul 14;19(17):1569-1580. doi: 10.1080/17435889.2024.2368454. Epub 2024 Jul 16.
Radiolabeling of bionanomaterials with technetium-99m (Tc) has become a promising approach in combining the benefits of nanotechnology and nuclear medicine for diagnostic and therapeutic purposes. This review is intended to provide a comprehensive overview of the state-of-the-art of radiolabeling of bionanomaterials with Tc, highlighting the synthesis methods, labeling mechanisms, biological evaluation, physicochemical characterization and clinical applications of Tc-labeled bionanomaterials. Various types of nanomaterials are considered in the review, including lipid- and protein-based nanosystems, dendrimers and polymeric nanomaterials. Moreover, the review assesses the challenges presented by this emerging field, such as stability of the radiolabel, potential toxicity of the nanomaterials and regulatory aspects. Finally, promising future perspectives and areas of research development in Tc-labeled bionanomaterials are discussed.
用锝-99m（Tc）对生物纳米材料进行放射性标记已成为一种很有前景的方法，可将纳米技术和核医学的优势结合起来用于诊断和治疗目的。本综述旨在全面概述用Tc对生物纳米材料进行放射性标记的最新进展，重点介绍Tc标记生物纳米材料的合成方法、标记机制、生物学评价、物理化学表征及临床应用。综述中考虑了各种类型的纳米材料，包括基于脂质和蛋白质的纳米系统、树枝状大分子和聚合物纳米材料。此外，该综述评估了这一新兴领域所面临的挑战，如放射性标记的稳定性、纳米材料的潜在毒性和监管方面。最后，讨论了Tc标记生物纳米材料未来有前景的发展前景和研究领域。
