血清 ITIH4 与 Th2 特征细胞因子、炎症、儿童哮喘恶化风险和严重程度的关联。
Linkage of serum ITIH4 with Th2 signature cytokine, inflammation, exacerbation risk and severity in childhood asthma.
机构信息
Second Department of Pediatrics, Xingtai People's Hospital, Xingtai, 054001, Hebei, China.
出版信息
Biomark Med. 2024;18(13-14):593-602. doi: 10.1080/17520363.2024.2366149. Epub 2024 Jul 16.
ITIH4 has anti-inflammatory properties toward eosinophilic/neutrophilic inflammation. This study aimed to explore clinical value of ITIH4 in childhood asthma. Serum ITIH4 and inflammatory cytokines were determined in 120 childhood asthma patients by enzyme-linked immunosorbent assay. In the entire and acute exacerbation patients, ITIH4 positively associated with IFN-γ, but negatively related to proinflammatory cytokines. ITIH4 was lowest in patients with acute exacerbation, followed by chronic persistent, and highest in clinical remission. By receiver-operating characteristic analysis, ITIH4 potentially estimated acute exacerbation asthma risk. Moreover, ITIH4 negatively related to exacerbation severity in acute exacerbation patients. Serum ITIH4 negatively links with Th2 cell signature cytokine, proinflammatory cytokines, exacerbation risk and severity in childhood asthma.
ITIH4 具有抗嗜酸性粒细胞/中性粒细胞炎症的特性。本研究旨在探讨 ITIH4 在儿童哮喘中的临床价值。采用酶联免疫吸附法测定 120 例儿童哮喘患者血清 ITIH4 和炎症细胞因子。在所有患者和急性加重期患者中，ITIH4 与 IFN-γ 呈正相关，与促炎细胞因子呈负相关。急性加重期患者 ITIH4 最低，慢性持续期次之，临床缓解期最高。通过受试者工作特征分析，ITIH4 可能估计急性加重期哮喘的风险。此外，在急性加重期患者中，ITIH4 与加重严重程度呈负相关。血清 ITIH4 与儿童哮喘 Th2 细胞特征细胞因子、促炎细胞因子、加重风险和严重程度呈负相关。
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