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本文引用的文献

1
The pathophysiology of the cell cycle in cancer and treatment strategies using various cell cycle checkpoint inhibitors.癌症中细胞周期的病理生理学以及使用各种细胞周期检查点抑制剂的治疗策略。
Pathol Res Pract. 2023 Nov;251:154854. doi: 10.1016/j.prp.2023.154854. Epub 2023 Oct 4.
2
Tumor microenvironment responsive metal nanoparticles in cancer immunotherapy.肿瘤微环境响应性金属纳米颗粒在癌症免疫治疗中的应用。
Front Immunol. 2023 Jul 27;14:1237361. doi: 10.3389/fimmu.2023.1237361. eCollection 2023.
3
Therapeutic Targeting of DNA Replication Stress in Cancer.癌症中 DNA 复制应激的治疗靶向。
Genes (Basel). 2023 Jun 26;14(7):1346. doi: 10.3390/genes14071346.
4
Cu(I)/Cu(II) Released by Cu Nanoparticles Revealed Differential Cellular Toxicity Related to Mitochondrial Dysfunction.铜纳米颗粒释放的 Cu(I)/Cu(II) 揭示了与线粒体功能障碍相关的细胞毒性差异。
Environ Sci Technol. 2023 Jul 4;57(26):9548-9558. doi: 10.1021/acs.est.3c00864. Epub 2023 Jun 20.
5
Copper oxide nanoparticles: In vitro and in vivo toxicity, mechanisms of action and factors influencing their toxicology.氧化铜纳米颗粒：体外和体内毒性、作用机制以及影响其毒理学的因素。
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Sep;271:109682. doi: 10.1016/j.cbpc.2023.109682. Epub 2023 Jun 15.
6
Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy.癌症治疗用铜基纳米材料的最新进展：用于抗肿瘤治疗。
Molecules. 2023 Mar 1;28(5):2303. doi: 10.3390/molecules28052303.
7
Interruption of the long non-coding RNA HOTAIR signaling axis ameliorates chemotherapy-induced cachexia in bladder cancer.阻断长链非编码 RNA HOTAIR 信号通路可改善膀胱癌化疗引起的恶病质。
J Biomed Sci. 2022 Dec 6;29(1):104. doi: 10.1186/s12929-022-00887-y.
8
A review on algal mediated synthesis of metal and metal oxide nanoparticles and their emerging biomedical potential.藻类介导的金属及金属氧化物纳米粒子合成及其新兴生物医学潜力综述。
J Biotechnol. 2022 Dec 10;360:92-109. doi: 10.1016/j.jbiotec.2022.10.009. Epub 2022 Oct 19.
9
Biosynthesis of copper oxide nanoparticles mediated Annona muricata as cytotoxic and apoptosis inducer factor in breast cancer cell lines.由番荔枝介导的氧化铜纳米粒子的生物合成作为乳腺癌细胞系中的细胞毒性和凋亡诱导因子。
Sci Rep. 2022 Sep 28;12(1):16165. doi: 10.1038/s41598-022-20360-y.
10
Functions and underlying mechanisms of lncRNA HOTAIR in cancer chemotherapy resistance.长链非编码RNA HOTAIR在癌症化疗耐药中的作用及潜在机制
Cell Death Discov. 2022 Sep 13;8(1):383. doi: 10.1038/s41420-022-01174-3.

绿色合成氧化铜纳米粒子诱导胰腺癌细胞凋亡，并上调 和 。

Green-synthesized copper oxide nanoparticles induce apoptosis and up-regulate and in pancreatic cancer cells.

机构信息

Department of Biological Science & Technology, Persian Gulf University, Bushehr 75169, Iran.

Persian Gulf Research Institute, Persian Gulf University, Bushehr 75169, Iran.

出版信息

Nanomedicine (Lond). 2024;19(18-20):1629-1641. doi: 10.1080/17435889.2024.2367958. Epub 2024 Jul 16.

DOI:10.1080/17435889.2024.2367958
PMID:39011923
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11389748/
Abstract

CuO nanoparticles were synthesized using an extract from algae (SLCuO NPs). Their effect on PANC-1 cells and the expression of two drug resistance-related lncRNAs were evaluated in comparison with Arsenic trioxide. SLCuO NPs were characterized using XRD, SEM, and TEM microscopies. The effects of SLCuO NPs on cell cytotoxicity, cell cycle, and apoptosis, and expression of two drug resistance-related lncRNAs were examined using MTT assay, flow cytometry, and real-time PCR, respectively. SLCuO NPs demonstrated anti-cancer properties against PANC-1 cells comparable to Arsenic trioxide, and the expression of lncRNAs increased upon treatment with them. SLCuO NPs demonstrate anti-cancer properties against PANC-1 cells; however, using gene silencing strategies along with SLCuO NPs is suggested.

摘要

采用海藻提取物（SLCuO NPs）合成了氧化铜纳米粒子。并将其与三氧化二砷进行比较，评估了它们对 PANC-1 细胞的影响和两种与耐药性相关的 lncRNAs 的表达。采用 XRD、SEM 和 TEM 显微镜对 SLCuO NPs 进行了表征。采用 MTT 检测法、流式细胞术和实时 PCR 分别检测了 SLCuO NPs 对细胞毒性、细胞周期和细胞凋亡的影响，以及两种与耐药性相关的 lncRNAs 的表达。SLCuO NPs 对 PANC-1 细胞表现出与三氧化二砷相当的抗癌特性，并且在用其处理后 lncRNAs 的表达增加。SLCuO NPs 对 PANC-1 细胞具有抗癌特性；然而，建议采用 SLCuO NPs 与基因沉默策略联合使用。