绿色合成氧化铜纳米粒子诱导胰腺癌细胞凋亡，并上调 和 。
Green-synthesized copper oxide nanoparticles induce apoptosis and up-regulate and in pancreatic cancer cells.
机构信息
Department of Biological Science & Technology, Persian Gulf University, Bushehr 75169, Iran.
Persian Gulf Research Institute, Persian Gulf University, Bushehr 75169, Iran.
出版信息
Nanomedicine (Lond). 2024;19(18-20):1629-1641. doi: 10.1080/17435889.2024.2367958. Epub 2024 Jul 16.
CuO nanoparticles were synthesized using an extract from algae (SLCuO NPs). Their effect on PANC-1 cells and the expression of two drug resistance-related lncRNAs were evaluated in comparison with Arsenic trioxide. SLCuO NPs were characterized using XRD, SEM, and TEM microscopies. The effects of SLCuO NPs on cell cytotoxicity, cell cycle, and apoptosis, and expression of two drug resistance-related lncRNAs were examined using MTT assay, flow cytometry, and real-time PCR, respectively. SLCuO NPs demonstrated anti-cancer properties against PANC-1 cells comparable to Arsenic trioxide, and the expression of lncRNAs increased upon treatment with them. SLCuO NPs demonstrate anti-cancer properties against PANC-1 cells; however, using gene silencing strategies along with SLCuO NPs is suggested.
采用海藻提取物（SLCuO NPs）合成了氧化铜纳米粒子。并将其与三氧化二砷进行比较，评估了它们对 PANC-1 细胞的影响和两种与耐药性相关的 lncRNAs 的表达。采用 XRD、SEM 和 TEM 显微镜对 SLCuO NPs 进行了表征。采用 MTT 检测法、流式细胞术和实时 PCR 分别检测了 SLCuO NPs 对细胞毒性、细胞周期和细胞凋亡的影响，以及两种与耐药性相关的 lncRNAs 的表达。SLCuO NPs 对 PANC-1 细胞表现出与三氧化二砷相当的抗癌特性，并且在用其处理后 lncRNAs 的表达增加。SLCuO NPs 对 PANC-1 细胞具有抗癌特性；然而，建议采用 SLCuO NPs 与基因沉默策略联合使用。
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