Almalki Sami G
Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah 11952, Saudi Arabia.
Pathol Res Pract. 2023 Nov;251:154854. doi: 10.1016/j.prp.2023.154854. Epub 2023 Oct 4.
The cell cycle is the series of events that occur in a cell leading to its division and duplication. It can be divided into two main stages: interphase and mitosis. Interphase is the longest stage of the cell cycle and can be further divided into three phases: G1, S, and G2. During G1, the cell grows and prepares for DNA synthesis. In the S phase, DNA synthesis occurs, leading to the replication of the genetic material. In G2, the cell continues to grow and prepares for mitosis. After mitosis, the cell enters the final stage of the cell cycle, called cytokinesis, during which the cytoplasm is divided, resulting in two separate daughter cells. The cell cycle then begins again with interphase. Cell cycle dysregulation is a hallmark of cancer, and it can have several consequences that contribute to the development and progression of cancer. Cyclin inhibitors and checkpoint activators have shown promise in the treatment of cancer, particularly in combination with other therapies.
细胞周期是细胞中发生的一系列导致其分裂和复制的事件。它可分为两个主要阶段：间期和有丝分裂。间期是细胞周期中最长的阶段，可进一步分为三个阶段：G1期、S期和G2期。在G1期，细胞生长并为DNA合成做准备。在S期，发生DNA合成，导致遗传物质的复制。在G2期，细胞继续生长并为有丝分裂做准备。有丝分裂后，细胞进入细胞周期的最后阶段，称为胞质分裂，在此期间细胞质被分裂，产生两个独立的子细胞。然后细胞周期又从间期开始。细胞周期失调是癌症的一个标志，它可能有几种后果，有助于癌症的发生和发展。细胞周期蛋白抑制剂和检查点激活剂在癌症治疗中显示出前景，特别是与其他疗法联合使用时。
