Design and evaluation of Ra/Tc-loaded spherical nano-hydroxyapatite in bone tumor therapy.

Nano-hydroxyapatite (nHA) is a good nanocarrier to load Ra, but the low specific activity (sp.act.) of Ra@nHA limits its application in medicine. We proposed a method for preparing nHA using PEG as a template, which significantly increases the sp.act of Ra@nHA and a new method to loaded Tc for tracking. The nHA synthesized using PEG as a template was associated with higher sp.act for Ra in comparison to nHA with identical particle size and without PEG. The nHA load Tc-MDP was associated with higher labeling rate and stability in comparison to Tc. All these findings suggest that using PEG as a template and Tc-MDP could be the most effective of synthetic Ra/Tc@nHA.