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CD44v6 和 MMP2 的共表达预测骨肉瘤的肺转移和不良预后。

Co-expression of CD44v6 and MMP2 predicts lung metastasis and unfavorable prognosis in osteosarcoma.

机构信息

Department of orthopedic, The Second Hospital of Tangshan, No.21, Jianshe North Road, Tangshan 063000, China.

出版信息

Future Oncol. 2024;20(25):1799-1806. doi: 10.1080/14796694.2024.2370234. Epub 2024 Jul 16.

DOI:10.1080/14796694.2024.2370234
PMID:39011948
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11485780/
Abstract

To evaluate the prognostic significance of CD44 variant v6 (CD44v6) and matrix metalloproteinases 2 (MMP2) expression in patients with surgically resected osteosarcoma. CD44v6 and MMP2 expression were immunohistochemically detected in 113 primary osteosarcoma patients at our institute between 2001 and 2019. Both CD44v6 and MMP2 were independent predictors for metastasis-free and overall survival. An extended predictive range and improved sensitivity were observed when the combined effects of CD44v6 and MMP2 were considered. Specifically, patients with CD44v6+ and MMP2+ expression were more susceptible to lung metastasis and exhibited the poorest survival rates compared with the other groups. The combination of CD44v6 and MMP2 may serve as a precise prognostic indicator for predicting metastatic progression and survival outcomes in patients with osteosarcoma.

摘要

为了评估 CD44 变体 v6（CD44v6）和基质金属蛋白酶 2（MMP2）在手术切除的骨肉瘤患者中的预后意义。我们研究所在 2001 年至 2019 年间对 113 例原发性骨肉瘤患者进行了 CD44v6 和 MMP2 的免疫组织化学检测。CD44v6 和 MMP2 都是无转移生存和总生存的独立预测因素。当考虑到 CD44v6 和 MMP2 的联合作用时，观察到预测范围的扩大和敏感性的提高。具体来说，与其他组相比，CD44v6+和 MMP2+表达的患者更容易发生肺转移，并且生存率最差。CD44v6 和 MMP2 的联合可能是预测骨肉瘤患者转移进展和生存结果的精确预后指标。

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本文引用的文献

[1]
The clinical significance of CD44v6 in malignant and benign primary bone tumors.

BMC Musculoskelet Disord. 2023-7-25

[2]
CD44 expression is correlated with osteosarcoma cell progression and immune infiltration and affects the Wnt/β-catenin signaling pathway.

J Bone Oncol. 2023-5-25

[3]
Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma.

Clin Cancer Res. 2022-2-15

[4]
Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment.

Gut. 2022-3

[5]
SPAG5 promotes osteosarcoma metastasis via activation of FOXM1/MMP2 axis.

Int J Biochem Cell Biol. 2020-9

[6]
Exosome-transmitted circ_MMP2 promotes hepatocellular carcinoma metastasis by upregulating MMP2.

Mol Oncol. 2020-6

[7]
CD44/CD44v6 a Reliable Companion in Cancer-Initiating Cell Maintenance and Tumor Progression.

Front Cell Dev Biol. 2018-8-28

[8]
The biology and role of CD44 in cancer progression: therapeutic implications.

J Hematol Oncol. 2018-5-10

[9]
NCCN Guidelines Insights: Bone Cancer, Version 2.2017.

J Natl Compr Canc Netw. 2017-2

[10]
Association of MMP-2 expression and prognosis in osteosarcoma patients.

Int J Clin Exp Pathol. 2015-11-1

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