Adaptive Phage Therapeutics, Gaithersburg, Maryland, USA.
The Wistar Institute, Philadelphia, Pennsylvania, USA.
J Infect Dis. 2024 Oct 16;230(4):912-918. doi: 10.1093/infdis/jiae362.
Host metabolic dysregulation, especially in tryptophan metabolism, is intricately linked to coronavirus disease 2019 (COVID-19) severity and its postacute sequelae (long COVID). People living with human immunodeficiency virus (HIV; PLWH) experience similar metabolic dysregulation and face an increased risk of developing long COVID. However, whether preexisting HIV-associated metabolic dysregulations contribute in predisposing PLWH to severe COVID-19 outcomes remains underexplored. Analyzing prepandemic samples from PLWH with documented postinfection outcomes, we found specific metabolic alterations, including increased tryptophan catabolism, predicting an elevated risk of severe COVID-19 and the incidence of long COVID. These alterations warrant further investigation for their potential prognostic and mechanistic significance in determining COVID-19 complications.
宿主代谢失调，尤其是色氨酸代谢，与 2019 年冠状病毒病（COVID-19）的严重程度及其急性后期（长新冠）密切相关。人类免疫缺陷病毒（HIV）感染者（PLWH）也经历类似的代谢失调，面临更高的长新冠发病风险。然而，HIV 相关代谢失调是否会预先导致 PLWH 更容易发展为严重的 COVID-19 结局，这方面仍研究不足。我们分析了有感染后记录结局的 PLWH 的大流行前样本，发现了特定的代谢改变，包括色氨酸分解代谢增加，提示其发生严重 COVID-19 和长新冠的风险增加。这些改变值得进一步研究，以确定其在预测 COVID-19 并发症方面的预后和机制意义。
