College of Biomedical Engineering, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China.
State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
J Mater Chem B. 2024 Aug 14;12(32):7879-7891. doi: 10.1039/d4tb00759j.
Near-infrared (NIR) light, compared with ultraviolet (UV) light, has a stronger tissue penetration ability and is widely used in the medical field. However, few hydrogels can be triggered by NIR. Here, a modular polymer-nanosheet (metal disulfide) (PNS) hydrogel system was proposed, which can be photo-crosslinked through photothermal conversion under NIR light. MoS, a transition-metal dichalcogenide, was used as a crosslink center in PNS hydrogels. Mo and S (from thiolated polymers), which are essential for gelation, were discovered to have new bonds. Furthermore, 3D printing of NIR-triggered PNS hydrogels was achieved conceptually with masked NIR. Moreover, multiple hydrogels and metal disulfides were applicable in this modular gelation system. This study indicated that these PNS hydrogels have great potential in many smart biomedical applications, including wearable sensors, noninvasive 3D bioprinting, and tissue repair substitutes.
近红外 (NIR) 光与紫外线 (UV) 相比，具有更强的组织穿透能力，因此被广泛应用于医学领域。然而，能够被近红外光触发的水凝胶却很少。在这里，我们提出了一种模块化聚合物-纳米片（金属二硫化物）（PNS）水凝胶体系，它可以通过近红外光下的光热转换进行光交联。作为一种过渡金属二硫化物，MoS 被用作 PNS 水凝胶中的交联中心。我们发现 Mo 和 S（来自巯基化聚合物）与凝胶形成有关的新键。此外，我们还通过掩模近红外光实现了 NIR 触发的 PNS 水凝胶的 3D 打印。此外，该模块化凝胶体系还适用于多种水凝胶和金属二硫化物。这项研究表明，这些 PNS 水凝胶在许多智能生物医学应用中具有巨大的潜力，包括可穿戴传感器、非侵入式 3D 生物打印和组织修复替代物。
