Hofmann-Preiß K
, Frankenstraße 24, 91096, Möhrendorf, Deutschland.
Radiologie (Heidelb). 2024 Aug;64(8):636-642. doi: 10.1007/s00117-024-01342-9. Epub 2024 Jul 16.
A variety of workplace exposures (organic or inorganic dusts as well as gases, fumes, or vapors) can cause diffuse interstitial lung disease. The latency period until onset of the disease can exceed 30 years. The disease course varies greatly and depends on the quantity of the inhaled substance and its fibrogenic effect. Pulmonary high-resolution computed tomography (HRCT) patterns do not differ significantly from those of interstitial lung diseases (ILD) of other etiologies. Therefore, without knowledge of the occupational history, work-related ILDs are often classified as idiopathic. In addition, there is increasing evidence in the recent literature that high exposure to silica dust can trigger autoimmune diseases (also involving the lungs). For this reason, a qualified occupational history is now an indispensable part of the interdisciplinary diagnosis of ILDs.
多种工作场所暴露因素（有机或无机粉尘以及气体、烟雾或蒸气）可导致弥漫性间质性肺疾病。该病发病的潜伏期可能超过30年。病程差异很大，取决于吸入物质的数量及其致纤维化作用。肺部高分辨率计算机断层扫描（HRCT）表现与其他病因的间质性肺疾病（ILD）并无显著差异。因此，在不了解职业史的情况下，与工作相关的ILD常被归类为特发性。此外，近期文献中有越来越多的证据表明，高暴露于二氧化硅粉尘可引发自身免疫性疾病（也累及肺部）。因此，一份合格的职业史现在是ILD跨学科诊断中不可或缺的一部分。
