Department of Endodontics, Faculty of Dentistry, Istanbul Medipol University, Birlik Mah. Bahçeler Cad. No: 5 Esenler, Istanbul, Turkey.
Department of Medical Biochemistry Department, Health Sciences University, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.
Lasers Med Sci. 2024 Jul 16;39(1):182. doi: 10.1007/s10103-024-04117-9.
To evaluate the efficacy of SWEEPS mode of the Er: YAG laser(SL) and passive ultrasonic irrigation(PUI) in the eradication of microorganisms and in the inflammation detection by IL-1β. Thirty patients with chronic apical periodontitis(AP) were allocated into two groups: Group SL-SWEEPS laser activated irrigation(n = 15) and Group PUI-passive ultrasonic irrigation(n = 15). Bacteriological samples were taken before(S1) and after chemomechanical preparation(S2), and then after final irrigation activation(S3). The levels of total bacteria and Streptococci were measured by means of PCR. Blood samples were collected before and 3rd day after treatment. Enzyme-linked immunosorbent assay was used to measure the levels of IL-1β. The bacterial reduction showed no differences between groups after chemo-mechanical treatment and after irrigant activation(p = 0.590). Post-treatment IL-1β levels were lower than pretreatment levels in both groups(p < 0.001). SL or PUI application in addition to chemomechanical preparation has similar effects on total bacterial level and inflammation detected by IL-1β in patients with AP.
为了评估 Er: YAG 激光（SL）的 SWEEPS 模式和被动超声冲洗（PUI）在消灭微生物和检测白细胞介素-1β（IL-1β）炎症方面的疗效。将 30 名患有慢性根尖周炎（AP）的患者分为两组：SL-SWEEPS 激光激活冲洗组（n=15）和 PUI-被动超声冲洗组（n=15）。在化学机械预备前（S1）、预备后（S2），然后在最终冲洗激活后（S3）采集细菌学样本。采用聚合酶链反应（PCR）测量总细菌和链球菌的数量。在治疗前和治疗后第 3 天采集血样。酶联免疫吸附试验（ELISA）用于测量 IL-1β 水平。化学机械治疗后和冲洗激活后，两组的细菌减少无差异（p=0.590）。两组治疗后的白细胞介素-1β水平均低于治疗前（p<0.001）。在 AP 患者中，除了化学机械预备之外，SL 或 PUI 的应用对总细菌水平和 IL-1β 检测的炎症具有相似的效果。
