Gordon M A, Norton S W
Sabouraudia. 1985 Aug;23(4):295-301.
Paecilomyces lilacinus was cultured from an ulcerated corneal transplant, sections of which, following surgical removal, revealed dense mycelial growth throughout the corneal remnant and penetrating Descemet's membrane. PAS-stained sections showed, in addition to the hyphae, numerous small, ovoid elements consistent with conidia of P. lilacinus. Infection apparently had spread to the transplant from the recipient's cornea. The fungal isolate proved resistant, in vitro, to amphotericin B, 5-fluorocytosine, and pimaricin, but sensitive to ketoconazole and moderately sensitive to miconazole. Following a second transplant and intensive antifungal therapy, the infection appears to have been eliminated.
从一例溃疡的角膜移植片中培养出淡紫拟青霉，手术切除后的移植片切片显示，在整个角膜残余组织中有密集的菌丝生长，并穿透了Descemet膜。过碘酸-雪夫（PAS）染色切片显示，除了菌丝外，还有许多与淡紫拟青霉分生孢子一致的小卵形结构。感染显然是从受者角膜扩散到移植片的。该真菌分离株在体外对两性霉素B、5-氟胞嘧啶和匹马霉素耐药，但对酮康唑敏感，对咪康唑中度敏感。在进行第二次移植并强化抗真菌治疗后，感染似乎已被消除。
