Castro L G, Salebian A, Sotto M N
Departamento de Dermatologia, Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, Brazil.
J Med Vet Mycol. 1990;28(1):15-26.
A case of hyalohyphomycosis caused by Paecilomyces lilacinus is described in a renal transplant patient. Infection was localized on the left forearm. Two separate cultures of the lesions yielded the same organism. Histological sections disclosed hyaline elements in the tissue. The infection responded well to therapy with oral griseofulvin (500 mg daily) and the patient was cured within 45 days. Forty-six cases of human infection due to Paecilomyces species have been reported previously in the literature, most of them occurring in conjunction with prosthesis implants or immunosuppression. The antifungal sensitivity of Paecilomyces varies widely among the species but the general trend is for Paecilomyces variotii isolates to be almost universally sensitive to amphotericin B and 5-fluorocytosine, while P. lilacinus and Paecilomyces marquandii isolates are resistant to these antifungals but sensitive to the imidazoles.
本文描述了1例肾移植患者由淡紫拟青霉引起的透明丝孢霉病。感染局限于左前臂。对病变组织进行的两次独立培养均得到相同的病原体。组织学切片显示组织中有透明成分。口服灰黄霉素（每日500mg）治疗对该感染效果良好，患者在45天内治愈。此前文献中已报道过46例由拟青霉属引起的人类感染病例，其中大多数与假体植入或免疫抑制有关。拟青霉属各菌种的抗真菌敏感性差异很大，但总体趋势是，变幻青霉分离株几乎对两性霉素B和5-氟胞嘧啶普遍敏感，而淡紫拟青霉和马昆德拟青霉分离株对这些抗真菌药物耐药，但对咪唑类敏感。
