急性髓系白血病中通过维生素D受体途径的BMP4信号传导实现的人类髓系分化 - Suppr

Human myeloid differentiation by BMP4 signaling through the VDR pathway in acute myeloid leukemia.

作者信息

Zylbersztejn Florence, Byelinska Iryna, Jeanpierre Sandrine, Barral Léa, Geistlich Kevin, Flores-Violante Mario, Voeltzel Thibault, Paubelle Etienne, Heiblig Mael, Alcazer Vincent, Le Meur Gregoire, Fossard Gaelle, Belhabri Amine, Cruz-Moura Ivan, Hermine Olivier, Lefort Sylvain, Maguer-Satta Véronique

机构信息

CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69000, Lyon, France.

Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69000, Lyon, France.

出版信息

Cell Death Discov. 2024 Jul 16;10(1):325. doi: 10.1038/s41420-024-02090-4.

DOI:10.1038/s41420-024-02090-4

PMID:39013874

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11252393/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09a7/11252393/8779a61a9cb4/41420_2024_2090_Fig1_HTML.jpg

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Human myeloid differentiation by BMP4 signaling through the VDR pathway in acute myeloid leukemia.急性髓系白血病中通过维生素D受体途径的BMP4信号传导实现的人类髓系分化

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Dynamic responses of the haematopoietic stem cell niche to diverse stresses.造血干细胞龛对多种应激的动态反应。

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A new signaling cascade linking BMP4, BMPR1A, ΔNp73 and NANOG impacts on stem-like human cell properties and patient outcome.一条新的信号级联途径将 BMP4、BMPR1A、ΔNp73 和 NANOG 联系起来，影响类干细胞特性和患者预后。

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Immature CML cells implement a BMP autocrine loop to escape TKI treatment.不成熟的 CML 细胞实施 BMP 自分泌环以逃避 TKI 治疗。

Blood. 2017 Dec 28;130(26):2860-2871. doi: 10.1182/blood-2017-08-801019. Epub 2017 Nov 14.

A 17-gene stemness score for rapid determination of risk in acute leukaemia.一种用于快速确定急性白血病风险的 17 基因干性评分。

Nature. 2016 Dec 15;540(7633):433-437. doi: 10.1038/nature20598. Epub 2016 Dec 7.

Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis.骨形态发生蛋白通路在发育性造血和白血病发生中的作用。

Biochem Soc Trans. 2016 Oct 15;44(5):1455-1463. doi: 10.1042/BST20160104.

A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy.骨形态发生蛋白诱导的同源框基因MIXL1在急性髓性白血病中的作用及I型骨形态发生蛋白受体作为潜在治疗靶点的鉴定。

Oncotarget. 2014 Dec 30;5(24):12675-93. doi: 10.18632/oncotarget.2564.

Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression.原始 CML 细胞的扩增依赖于龛内提供的异常水平的 BMPs 和 BMPRIb 的过表达。

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Human myeloid differentiation by BMP4 signaling through the VDR pathway in acute myeloid leukemia.

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