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[儿童内镜逆行胰胆管造影术后胰腺炎的危险因素]

[Risk factors for pancreatitis after endoscopic retrograde cholangiopancreatography in children].

作者信息

Yang Lu, Fu Yan, Sun Zheng-Hao, Zhou Jia, Tang Juan, Ni Jing

机构信息

Department of Gastroenterology, Second Affiliated Hospital of Kunming Medical University, Kunming 650032, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2024 Jul 15;26(7):690-694. doi: 10.7499/j.issn.1008-8830.2402047.

DOI:10.7499/j.issn.1008-8830.2402047
PMID:39014944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11562034/
Abstract

OBJECTIVES

To investigate the application of endoscopic retrograde cholangiopancreatography (ERCP) in children and the risk factors for post-ERCP pancreatitis (PEP).

METHODS

A retrospective analysis was conducted on the clinical data of 66 children, aged ≤16 years, who underwent ERCP for pancreaticobiliary diseases at the Gastrointestinal Endoscopy Center of the Second Affiliated Hospital of Kunming Medical University from September 2013 to September 2023. The incidence rate of PEP and the risk factors for the development of PEP were analyzed.

RESULTS

A total of 78 ERCP procedures were performed on 66 children, with 5 diagnostic ERCPs, 69 therapeutic ERCPs, and 4 failed procedures. The success rate of ERCP operations was 95% (74/78). There were 17 cases of PEP in total, with an incidence rate of 22%. In the PEP group, the proportion of children with normal preoperative bilirubin and the proportion of guidewire insertion into the pancreatic duct during surgery were higher than in the non-PEP group (<0.05). The multivariate logistic regression analysis showed that guidewire insertion into the pancreatic duct was an independent risk factor for PEP (<0.05).

CONCLUSIONS

With the increasing application of ERCP in children with pancreaticobiliary diseases, it is important to select an appropriate intubation technique during surgery to avoid blindly entering the guidewire into the pancreatic duct and reduce the occurrence of PEP.

摘要

目的

探讨内镜逆行胰胆管造影术(ERCP)在儿童中的应用及ERCP术后胰腺炎(PEP)的危险因素。

方法

对2013年9月至2023年9月在昆明医科大学第二附属医院胃肠内镜中心接受ERCP治疗胰胆疾病的66例16岁及以下儿童的临床资料进行回顾性分析。分析PEP的发生率及PEP发生的危险因素。

结果

66例儿童共行78次ERCP操作,其中诊断性ERCP 5例,治疗性ERCP 69例,操作失败4例。ERCP手术成功率为95%(74/78)。共发生PEP 17例,发生率为22%。PEP组术前胆红素正常的儿童比例及术中导丝插入胰管的比例高于非PEP组(<0.05)。多因素logistic回归分析显示,导丝插入胰管是PEP的独立危险因素(<0.05)。

结论

随着ERCP在儿童胰胆疾病中的应用日益增多,术中选择合适的插管技术,避免盲目将导丝插入胰管,减少PEP的发生至关重要。

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