The challenges and opportunities of developing small molecule inhibitors of MraY.
作者信息
Manning Destinee, Huang Tzu-Yu, Berida Tomayo, Roy Sudeshna
机构信息
Department of BioMolecular Sciences, University of Mississippi, University, MS, United States.
出版信息
Annu Rep Med Chem. 2023;60:1-27. doi: 10.1016/bs.armc.2023.09.005. Epub 2023 Oct 11.
Abstract
摘要
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Nucleic Acids Res. 2023 Jan 6;51(D1):D523-D531. doi: 10.1093/nar/gkac1052.
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Peptidomimetic analogues of an Arg-Trp-x-x-Trp motif responsible for interaction of translocase MraY with bacteriophage ϕX174 lysis protein E.负责 MraY 转位酶与噬菌体 ϕX174 裂解蛋白 E 相互作用的 Arg-Trp-x-x-Trp 基序的肽模拟物。
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Identification of potential non-nucleoside MraY inhibitors for tuberculosis chemotherapy using structure-based virtual screening.基于结构的虚拟筛选鉴定潜在的抗结核分枝杆菌非核苷 MraY 抑制剂
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J Antibiot (Tokyo). 2019 Dec;72(12):865-876. doi: 10.1038/s41429-019-0227-3. Epub 2019 Aug 30.
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