Le Lingying, Lan Ziwei, Chen Chenxi
Department of Neurology, West China Xiamen Hospital of Sichuan University, Xiamen, China.
Department of Neurology, The Second Xiangya Hospital of Central South University, Changsha, China.
Front Aging Neurosci. 2024 Jul 2;16:1391176. doi: 10.3389/fnagi.2024.1391176. eCollection 2024.
Ethylene oxide (EtO), a highly reactive organic compound with extensive industrial applications, poses significant health risks. The association between EtO exposure and stroke was not well established. This study examined the association between EtO exposure and stroke among US adults using data from the 2013-2018 National Health and Nutrition Examination Survey (NHANES).
We used appropriately weighted multifactorial logistic regression models to analyze the data and validated the findings with smoothed curve fitting. Stratified analysis and interaction assessments were performed to evaluate the robustness of the findings.
The study included 5,071 participants, balanced between men and women, with a stroke prevalence of 4.1%. Higher EtO levels were associated with rising rates of stroke (OR = 1.23, 95% CI: 1.06-1.42). Individuals in the top 25% group displayed a stroke prevalence 1.6 times higher than those in the bottom 25% group (OR = 1.60, 95%CI: 1.03-2.48). Stratified analysis demonstrated a significant positive association between EtO and stroke in individuals under 50 years (OR = 1.94, 95%CI: 1.38-2.72), while no significant association was found in those aged 50 and above (OR = 0.97, 95%CI: 0.83-1.14).
This study identified a significant association between EtO exposure and stroke occurrence in young adults in the United States.
环氧乙烷（EtO）是一种具有广泛工业应用的高反应性有机化合物，会带来重大健康风险。环氧乙烷暴露与中风之间的关联尚未明确确立。本研究利用2013 - 2018年美国国家健康与营养检查调查（NHANES）的数据，调查了美国成年人中环氧乙烷暴露与中风之间的关联。
我们使用适当加权的多因素逻辑回归模型分析数据，并通过平滑曲线拟合验证研究结果。进行分层分析和交互作用评估以评估研究结果的稳健性。
该研究纳入了5071名参与者，男女比例均衡，中风患病率为4.1%。环氧乙烷水平越高，中风发生率越高（OR = 1.23，95%CI：1.06 - 1.42）。处于前25%组的个体中风患病率比处于后25%组的个体高1.6倍（OR = 1.60，95%CI：1.03 - 2.48）。分层分析表明，在50岁以下个体中，环氧乙烷与中风之间存在显著正相关（OR = 1.94，95%CI：1.38 - 2.72），而在50岁及以上个体中未发现显著关联（OR = 0.97，95%CI：0.83 - 1.14）。
本研究确定了美国年轻人中环氧乙烷暴露与中风发生之间存在显著关联。
