Choi Hansol, Choy Yoon-Soo
Department of Preventive Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
Department of Smart Healthcare Information, Healthcare Management, Eulji University, 553 Sanseong-daero, Sujeong-gu, Seongnam-si 13135, Republic of Korea.
Healthcare (Basel). 2024 Dec 11;12(24):2499. doi: 10.3390/healthcare12242499.
: This study aims to investigate the effects of ethylene oxide (EO) exposure on sleep health, focusing on sleep duration and quality. : The study analyzed data from the NHANES (National Health and Nutrition Examination Survey) 2015-2020 cycles, including 4268 participants aged 20 and older. EO exposure was measured using hemoglobin adducts of EO (HbEO), which serve as a reliable biomarker. Sleep health was assessed through self-reported questionnaires on sleep duration and quality. Participants were categorized based on sleep duration (<6 h, 6-9 h, >9 h) and symptoms of sleep disturbances. Statistical analyses employed survey-weighted logistic regression models to evaluate the associations between HbEO levels and sleep outcomes, adjusting for sociodemographic, health-related, and behavioral factors. Moreover, to examine whether the impact of ethylene oxide exposure on sleep quality and sleep duration varies by sociodemographic characteristics, stratified analyses were conducted based on gender, age, marital status, and employment type. : According to the results, higher EO exposure was associated with shorter sleep durations and increased likelihood of sleep disturbances. Moreover, according to sub-group analysis by sex, men with higher exposure to EO, were likely to have short sleep duration, and women with higher exposure to EO had higher risk of daytime sleepiness and sleep problems. : The findings suggest that EO exposure may negatively impact sleep health, emphasizing the need for stricter EO exposure regulations and public health interventions to reduce associated risks.
本研究旨在调查环氧乙烷（EO）暴露对睡眠健康的影响，重点关注睡眠时间和质量。该研究分析了2015 - 2020年美国国家健康与营养检查调查（NHANES）周期的数据，包括4268名20岁及以上的参与者。使用环氧乙烷血红蛋白加合物（HbEO）来测量环氧乙烷暴露，HbEO是一种可靠的生物标志物。通过关于睡眠时间和质量的自我报告问卷来评估睡眠健康。参与者根据睡眠时间（<6小时、6 - 9小时、>9小时）和睡眠障碍症状进行分类。统计分析采用调查加权逻辑回归模型来评估HbEO水平与睡眠结果之间的关联，并对社会人口统计学、健康相关和行为因素进行了调整。此外，为了研究环氧乙烷暴露对睡眠质量和睡眠时间的影响是否因社会人口统计学特征而异，还根据性别、年龄、婚姻状况和就业类型进行了分层分析。根据结果，较高的环氧乙烷暴露与较短的睡眠时间和睡眠障碍可能性增加有关。此外，根据性别进行的亚组分析显示，环氧乙烷暴露较高的男性可能睡眠时间较短，而环氧乙烷暴露较高的女性白天嗜睡和睡眠问题的风险较高。研究结果表明，环氧乙烷暴露可能对睡眠健康产生负面影响，强调需要更严格的环氧乙烷暴露法规和公共卫生干预措施以降低相关风险。
