[Virus-associated chronic autoimmune aggressive hepatitis (HBsAg seronegative) with pronounced diarrhea].

It is reported on a 17-year-old male patient who in 1982 fell ill with a HBsAg-seronegative hepatitis with therapy-resistant diarrhoeas of high frequency and in whom immunohistologically a virus-associated autoimmune chronic aggressive hepatitis was established. As cause of severe diarrhoeas which underwent involution only after 2 months as a sequel of the azathioprin-prednisolone therapy the proof of HBsAg in Lieberkühn's crypts of the small intestine performed by means of direct immunofluorescence is assumed.