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一名接受硼替佐米治疗的华氏巨球蛋白血症患者出现听力损失

Hearing Loss in a Patient with Waldenstrom Macroglobulinemia Receiving Bortezomib.

作者信息

Fitzsimons Jack, Phelan Kathleen, Dhanarajan Asha

机构信息

Department of Medicine, Loyola University Medical Center, Maywood, IL, USA.

Division of Hematology and Oncology, Hines Veterans Affairs Hospital, Hines, IL, USA.

出版信息

Case Rep Oncol. 2024 Jun 18;17(1):653-657. doi: 10.1159/000539453. eCollection 2024 Jan-Dec.

DOI:10.1159/000539453
PMID:39015638
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11249454/
Abstract

INTRODUCTION

We present a case report of hearing loss in a patient with Waldenstrom macroglobulinemia (WM) receiving treatment with bortezomib.

CASE PRESENTATION

Our patient developed sudden bilateral sensorineural hearing loss after receiving three doses of bortezomib. His hearing loss was irreversible and resulted in a cochlear implant.

CONCLUSION

Hearing loss secondary to bortezomib is a known, but very rare, side effect. Hearing loss secondary to WM is also rare and has been described in case reports.

摘要

引言

我们报告一例接受硼替佐米治疗的华氏巨球蛋白血症（WM）患者出现听力丧失的病例。

病例介绍

我们的患者在接受三剂硼替佐米治疗后出现双侧突发性感音神经性听力丧失。他的听力丧失是不可逆的，最终接受了人工耳蜗植入。

结论

硼替佐米引起的听力丧失是一种已知但非常罕见的副作用。WM引起的听力丧失也很罕见，已有病例报告对此进行过描述。

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Relation between auditory difficulties and bortezomib-induced peripheral neuropathy in multiple myeloma: a single-center cross-sectional study.多发性骨髓瘤患者听觉障碍与硼替佐米诱导的周围神经病变之间的关系：一项单中心横断面研究
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