Wells M, Michaels L, Wells D G
Clin Otolaryngol Allied Sci. 1977 Nov;2(4):327-38. doi: 10.1111/j.1365-2273.1977.tb01376.x.
Four cases of Waldenstrom's macroglobulinaemia (WM) are described in which otoloaryngeal symptoms were present. Symptoms in WM are related to (a) bleeding diathesis and (b) hyperviscosity of the blood. The bleeding diathesis was manifested as epistaxis in 2 cases. In one case which came to postmortem, histological examination of the temporal bone showed complete disruption of the labyrinth by haemorrhage. Hyperviscosity probably was the source of hearing loss which took place in all 4 patients and had the following characteristics: (a) sudden onset (b) cochlear type (c) bilateral (d) sequential involvement of the two sides (e) improvement on treatment of the disease with alkylating agents or plasmapheresis. Early diagnosis of WM is thus important.
本文描述了4例伴有耳鼻喉症状的华氏巨球蛋白血症（WM）。WM的症状与（a）出血素质和（b）血液高黏滞性有关。出血素质在2例中表现为鼻出血。1例尸检病例的颞骨组织学检查显示，出血导致迷路完全破坏。高黏滞性可能是所有4例患者听力损失的原因，其具有以下特点：（a）突发；（b）耳蜗型；（c）双侧性；（d）双侧先后受累；（e）用烷化剂或血浆置换治疗疾病后听力改善。因此，WM的早期诊断很重要。
