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贝尔麻痹,新冠疫苗接种后的不良事件。

Bell's Palsy, an Adverse Event Following COVID Vaccines.

作者信息

Pyarali Maheen, Adeel Maira, Nawaz Ahmad, Uneeb Saher, Fazal Dad Ayesha-Bibi, Amir Saniya

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery.

Liaquat National Hospital, Karachi, Pakistan.

出版信息

Iran J Otorhinolaryngol. 2024 Jul;36(4):527-535. doi: 10.22038/IJORL.2024.69721.3364.

DOI:10.22038/IJORL.2024.69721.3364
PMID:39015690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11247443/
Abstract

INTRODUCTION

Bell's palsy is one of the most concerning complications of the COVID vaccine that has impacted vaccine acceptance among the general population. These vaccines were introduced to provide immunity against the SARS-CoV-2 coronavirus and have been found to be quite effective. Little did we know that Bell's palsy could be one of its serious complications.

MATERIALS AND METHODS

We used various search engines to gather data in the form of a case series and case reports related to patients who were affected by the vaccine and had developed Bell's palsy.

RESULTS

A total of eleven case reports and 4 case series were included in the analysis. The vaccines mentioned in the case reports were Pfizer, Moderna, Sinovac, AstraZeneca, and Janssen, while the case series included Pfizer and Sinovac. The majority of patients were female and aged between 31-40 years. Right-sided laterality was observed in 45.45% of patients, left-sided laterality in 45.45% of patients, and bilateral laterality in 9.1% of patients. Three patients had a history of Bell's palsy or stroke. After treatment, three patients showed partial improvement, six patients fully recovered, and the status of two patients was unknown.

CONCLUSIONS

Bell's palsy is a rare complication that can occur after receiving the COVID-19 vaccine. This review aims to increase awareness about this rare adverse event of the vaccine so that it can be properly addressed and managed. Additionally, it will serve as a foundation for future research on the administration of the COVID-19 vaccine.

摘要

引言

贝尔氏面瘫是新冠疫苗最令人担忧的并发症之一,影响了普通民众对疫苗的接受度。这些疫苗旨在提供针对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的免疫力,并且已被证明相当有效。我们几乎不知道贝尔氏面瘫可能是其严重并发症之一。

材料与方法

我们使用了各种搜索引擎,以病例系列和病例报告的形式收集与受疫苗影响并患上贝尔氏面瘫的患者相关的数据。

结果

分析共纳入了11份病例报告和4个病例系列。病例报告中提及的疫苗有辉瑞、莫德纳、科兴、阿斯利康和杨森,而病例系列包括辉瑞和科兴。大多数患者为女性,年龄在31至40岁之间。45.45%的患者为右侧面瘫,45.45%的患者为左侧面瘫,9.1%的患者为双侧面瘫。3名患者有贝尔氏面瘫或中风病史。治疗后,3名患者部分改善,6名患者完全康复,2名患者的状况未知。

结论

贝尔氏面瘫是接种新冠疫苗后可能出现的罕见并发症。本综述旨在提高对这种罕见疫苗不良事件的认识,以便能够妥善处理和管理。此外,它将为未来新冠疫苗接种的研究奠定基础。

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本文引用的文献

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A case of Miller Fisher syndrome with delayed onset peripheral facial nerve palsy after COVID-19 vaccination: a case report.一例接种 COVID-19 疫苗后出现迟发性周围性面神经麻痹的 Miller Fisher 综合征:病例报告。
BMC Neurol. 2022 Aug 22;22(1):309. doi: 10.1186/s12883-022-02838-4.
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Adverse events of special interest and mortality following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines in Hong Kong: A retrospective study.香港接种 mRNA(BNT162b2)和灭活(科兴)SARS-CoV-2 疫苗后特殊关注的不良事件和死亡率:一项回顾性研究。
PLoS Med. 2022 Jun 21;19(6):e1004018. doi: 10.1371/journal.pmed.1004018. eCollection 2022 Jun.
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Bell's Palsy After Second Dose of Moderna COVID-19 Vaccine: Coincidence or Causation?第二剂莫德纳新冠疫苗接种后出现贝尔氏麻痹:巧合还是因果关系?
Acta Med Litu. 2021;28(2):298-301. doi: 10.15388/Amed.2021.28.2.7. Epub 2021 Aug 4.
4
Miller Fisher syndrome following Pfizer COVID-19 vaccine.辉瑞 COVID-19 疫苗接种后出现米勒费希尔综合征。
Neurol Sci. 2022 Mar;43(3):1495-1497. doi: 10.1007/s10072-021-05776-0. Epub 2021 Nov 24.
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Left Bell's palsy following the first dose of mRNA-1273 SARS-CoV-2 vaccine: A case report.接种 mRNA-1273 新型冠状病毒疫苗后出现左侧贝尔麻痹:一例病例报告。
Clin Imaging. 2022 Feb;82:1-4. doi: 10.1016/j.clinimag.2021.10.010. Epub 2021 Nov 4.
6
Bell's palsy after inactivated COVID-19 vaccination in a patient with history of recurrent Bell's palsy: A case report.一名有复发性贝尔麻痹病史的患者在接种灭活新冠疫苗后发生贝尔麻痹:一例病例报告。
World J Clin Cases. 2021 Sep 26;9(27):8274-8279. doi: 10.12998/wjcc.v9.i27.8274.
7
Neurological symptoms and neuroimaging alterations related with COVID-19 vaccine: Cause or coincidence?与新冠疫苗相关的神经系统症状和神经影像学改变:是原因还是巧合?
Clin Imaging. 2021 Dec;80:348-352. doi: 10.1016/j.clinimag.2021.08.021. Epub 2021 Sep 7.
8
Bell's palsy following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines: a case series and nested case-control study.接种 mRNA(BNT162b2)和灭活(科兴)SARS-CoV-2 疫苗后出现贝尔麻痹:病例系列和巢式病例对照研究。
Lancet Infect Dis. 2022 Jan;22(1):64-72. doi: 10.1016/S1473-3099(21)00451-5. Epub 2021 Aug 16.
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Side effects and perceptions following Sinopharm COVID-19 vaccination.接种科兴新冠疫苗后的副作用和感受。
Int J Infect Dis. 2021 Oct;111:219-226. doi: 10.1016/j.ijid.2021.08.013. Epub 2021 Aug 9.
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