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mRNA-1273新型冠状病毒疫苗接种24小时后出现贝尔麻痹

Bell's Palsy After 24 Hours of mRNA-1273 SARS-CoV-2 Vaccine.

作者信息

Iftikhar Haris, Noor Syeda Mishkaat U, Masood Maarij, Bashir Khalid

机构信息

Emergency Medicine, Hamad Medical Corporation, Doha, QAT.

出版信息

Cureus. 2021 Jun 26;13(6):e15935. doi: 10.7759/cureus.15935. eCollection 2021 Jun.

Abstract

Coronavirus disease 2019 (COVID-19) has become the fastest-spreading pandemic of the 21st century. Various vaccines have been made available via emergency use authorization. Currently, two mRNA vaccines are being offered internationally, BNT162b2 and mRNA-1273. In randomized trials of these vaccines, the incidence of Bell's palsy in the vaccinated group does not statistically exceed the placebo group. The FDA recommends increased surveillance for Bell's palsy as a potential side effect with the administration of the vaccines among larger populations globally. There have been a few case reports of Bell's palsy associated with mRNA vaccines. Type I interferons have been proposed as the potential mechanism linking mRNA COVID-19 vaccines to Bell's palsy. Here, we report the case of a 36-year-old previously healthy patient who developed symptoms of Bell's palsy along with left-arm numbness, tingling, and subjective weakness masquerading as a subacute stroke after receiving the second dose of the mRNA-1273 vaccine. CT and MRI of the brain were unremarkable. He was discharged home with a diagnosis of Bell's palsy and improved on follow-up. mRNA COVID-19 vaccines may be considered a risk factor for Bell's palsy.

摘要

2019冠状病毒病(COVID-19)已成为21世纪传播速度最快的大流行病。多种疫苗已通过紧急使用授权获批使用。目前,两种信使核糖核酸(mRNA)疫苗正在国际上提供,即BNT162b2和mRNA-1273。在这些疫苗的随机试验中,接种疫苗组的贝尔麻痹发病率在统计学上并未超过安慰剂组。美国食品药品监督管理局(FDA)建议,在全球更多人群接种疫苗时,加强对贝尔麻痹这一潜在副作用的监测。已有一些与mRNA疫苗相关的贝尔麻痹病例报告。I型干扰素被认为是将mRNA COVID-19疫苗与贝尔麻痹联系起来的潜在机制。在此,我们报告一例36岁既往健康的患者,在接种第二剂mRNA-1273疫苗后出现贝尔麻痹症状,同时伴有左臂麻木、刺痛和主观无力,疑似亚急性卒中。脑部CT和MRI检查无异常。他出院时被诊断为贝尔麻痹,随访时病情有所改善。mRNA COVID-19疫苗可能被视为贝尔麻痹的一个风险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6126/8312995/35c14c8a3897/cureus-0013-00000015935-i01.jpg

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