Tan Fei-Fei, Liu He-Xu, Huang Xue-Yan, Yu Chang-Yin, Yang Xiao-Yan
Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China.
World J Clin Cases. 2024 Jul 16;12(20):4372-4376. doi: 10.12998/wjcc.v12.i20.4372.
The role of diverse antibodies in mediating peripheral nerve injury in Guillain-Barré syndrome (GBS) is becoming clearer, but positivity for multiple antibodies in one case is uncommon. To our knowledge, this is the first case involving GBS with positive anti-sulfatide, anti-GT1a, and anti-GT1b antibodies.
A 20-year-old female patient was admitted to the hospital due to weakness of limbs for 5 d, and deterioration of the weakness and muscle aches for 1 d. The patient's limbs were weak, but the tendon reflexes in the part of the limbs were normal. There was no comorbid peripheral nociception or deep sensory dysfunction. She was diagnosed with GBS and was discharged after receiving intravenous human immunoglobulin pulse therapy.
In this article, the clinical manifestations, neurophysiological examination, and auxiliary examination findings of a GBS patient positive for multiple antibodies were analyzed to improve the identification of the disease by clinical physicians at an early stage.
多种抗体在介导吉兰-巴雷综合征（GBS）外周神经损伤中的作用日益明确，但同一病例中多种抗体呈阳性并不常见。据我们所知，这是首例抗硫脂、抗GT1a和抗GT1b抗体阳性的GBS病例。
一名20岁女性患者因四肢无力5天入院，入院1天来肌无力及肌肉疼痛加重。患者四肢无力，但部分肢体的腱反射正常。无合并周围性痛觉或深感觉功能障碍。她被诊断为GBS，接受静脉注射人免疫球蛋白冲击治疗后出院。
本文分析了一名多种抗体阳性的GBS患者的临床表现、神经生理学检查及辅助检查结果，以提高临床医生对该病的早期识别。
