Liu Hua, Lv Hui-Gang, Zhang Rong
Department of Neurology, Yixing Hospital of Traditional Chinese Medicine, Yixing 214200, Jiangsu Province, China.
Department of Neurology, The First People's Hospital of Shizuishan City, Shizuishan 753200, Ningxia Hui Autonomous Region, China.
World J Clin Cases. 2023 Sep 16;11(26):6274-6279. doi: 10.12998/wjcc.v11.i26.6274.
Guillain-Barré syndrome (GBS) is an acute autoimmune-mediated polyneuropathy. Studies have increasingly reported the presence of anti-sulfatide antibody positivity with varying clinical symptoms in patients with GBS. However, spinal cord involvement is relatively rare in these cases.
A 68-year-old woman was admitted to the hospital with weakness of the limb for more than 3 d. Additional symptoms included neck pain, progressive numbness in the distal extremities, urinary and fecal retention, and reduced perception of temperature. She was diagnosed with an anti-sulfatide antibody-positive GBS variant and discharged after treatment with methylprednisolone and intravenous human immunoglobulin pulse therapy. Unlike common cases of anti-sulfatide antibody-positive GBS, this patient had atypical clinical symptoms of spinal cord involvement. No similar cases have previously been reported in China.
Although GBS is associated with a poor prognosis, a prompt diagnosis allows early administration of combined intravenous human immunoglobulin and methylprednisolone pulse therapy.
吉兰 - 巴雷综合征（GBS）是一种急性自身免疫介导的多发性神经病。研究越来越多地报道GBS患者存在抗硫脂抗体阳性且伴有不同临床症状。然而，这些病例中脊髓受累相对少见。
一名68岁女性因肢体无力3天以上入院。其他症状包括颈部疼痛、远端肢体进行性麻木、大小便潴留以及温度感知减退。她被诊断为抗硫脂抗体阳性GBS变异型，经甲泼尼龙和静脉注射人免疫球蛋白冲击治疗后出院。与抗硫脂抗体阳性GBS的常见病例不同，该患者有脊髓受累的非典型临床症状。此前中国未见类似病例报道。
虽然GBS预后较差，但及时诊断可早期给予静脉注射人免疫球蛋白和甲泼尼龙冲击联合治疗。
