Ha Yooseok, Kim Jeong-Hee, Kim Jiyoung, Kwon Hyeokjae
Department of Plastic and Reconstructive Surgery, Chungnam National University Hospital, Daejeon 35015, South Korea.
College of Nursing, Woosuk University, Wanju-gun 55338, South Korea.
World J Clin Cases. 2024 Jul 16;12(20):4446-4451. doi: 10.12998/wjcc.v12.i20.4446.
Diabetic foot ulcers are caused by a variety of factors, including peripheral neuropathy, peripheral arterial disease, impaired wound healing mechanisms, and repetitive trauma. Patients with diabetic foot ulcer on the dorsum of the foot are often treated surgically. However, the right non-surgical therapy must be chosen if surgical choices are contraindicated or if the patient prefers conservative treatment over surgery.
The purpose of this case report is to highlight the efficacy of polydeoxyribonucleotide (PDRN) injection as a non-surgical treatment option for diabetic foot ulcers on the dorsum of the foot, particularly in patients who choose against surgical intervention. This case report presents two cases of diabetic foot ulcers located on the dorsum of the foot that were successfully treated with PDRN injection as a non-surgical intervention.
If the patient declines surgery for diabetic ulcers with Wagner grade II or below, PDRN injection can be effective if necrotic tissue is removed and the wound bed kept clean.
糖尿病足溃疡由多种因素引起，包括周围神经病变、周围动脉疾病、伤口愈合机制受损以及反复创伤。足部背侧患有糖尿病足溃疡的患者通常接受手术治疗。然而，如果手术选择存在禁忌，或者患者更倾向于保守治疗而非手术，就必须选择正确的非手术治疗方法。
本病例报告的目的是强调聚脱氧核糖核苷酸（PDRN）注射作为足部背侧糖尿病足溃疡非手术治疗选择的疗效，特别是对于那些选择不进行手术干预的患者。本病例报告呈现了两例位于足部背侧的糖尿病足溃疡，通过PDRN注射作为非手术干预成功治愈。
如果患者拒绝接受瓦格纳分级为二级及以下的糖尿病溃疡手术治疗，在清除坏死组织并保持伤口床清洁的情况下，PDRN注射可能有效。
