Department of Otorhinolaryngology, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Laryngoscope. 2024 Dec;134(12):4858-4872. doi: 10.1002/lary.31646. Epub 2024 Jul 17.
The purpose of this study is to consolidate and condense the available evidence about the potential association between vestibular diseases and cognitive impairment.
A systematic search was conducted on four English databases (PubMed, Embase, Web of Science, Cochrane Library) from the time of library construction to March 2024. The study incorporated various keywords such as "vestibular disorders," "vertigo," "dizziness," "Meniere's disease," "benign paroxysmal positional vertigo," "vestibular migraine," "vestibular neuritis," "labyrinthitis," "bilateral vestibular disease," as well as "cognitive function" and "cognitive dysfunction." A qualitative review was conducted to look for and assess pertinent studies.
A total of 45 publications were incorporated, encompassing prevalent vestibular disorders, mostly targeting individuals in the middle-aged and older demographic. The findings indicate that individuals with vestibular disorders experience varying levels of cognitive impairment, which is evident in different aspects, with visuospatial cognitive deficits being more prominent. Furthermore, patients with chronic vestibular syndromes are more prone to cognitive dysfunction. Lastly, the hippocampus plays a crucial role in the intricate vestibular neural network.
The findings of this comprehensive review indicate that vestibular disorders can result in impairments across various aspects of cognitive functioning, particularly in visuospatial cognition. The underlying mechanism may be associated with a decrease in the size of the hippocampus. Individuals suffering from chronic vestibular dysfunction exhibit a higher likelihood of experiencing cognitive deficits.
NA Laryngoscope, 134:4858-4872, 2024.
本研究旨在整合和浓缩有关前庭疾病与认知障碍之间潜在关联的现有证据。
从建库时间到 2024 年 3 月，我们在四个英文数据库（PubMed、Embase、Web of Science、Cochrane Library）上进行了系统检索。该研究采用了各种关键词，如“前庭障碍”、“眩晕”、“头晕”、“梅尼埃病”、“良性阵发性位置性眩晕”、“前庭性偏头痛”、“前庭神经炎”、“迷路炎”、“双侧前庭疾病”以及“认知功能”和“认知功能障碍”。我们进行了定性综述，以寻找和评估相关研究。
共纳入 45 篇文献，涵盖了常见的前庭障碍，主要针对中老年人群。研究结果表明，患有前庭障碍的个体表现出不同程度的认知障碍，在不同方面都有体现，其中视空间认知缺陷更为突出。此外，慢性前庭综合征患者更容易出现认知功能障碍。最后，海马在复杂的前庭神经网络中起着关键作用。
这项全面综述的结果表明，前庭障碍会导致认知功能的多个方面受损，特别是在视空间认知方面。其潜在机制可能与海马体积缩小有关。患有慢性前庭功能障碍的个体更有可能出现认知缺陷。
无。Laryngoscope, 134:4858-4872, 2024.
