Jia Yuan, Zhang Yue, Bai Shiru, Liu Jia, Chen Tianlei, Liu Xuda, Xu Chao, Zhang Ruining, Du Rongpin
Department of Cardiology, Hebei General Hospital, Shijiazhuang, China.
Department of Cardiology, Hebei Medical University, Shijiazhuang, China.
ESC Heart Fail. 2024 Dec;11(6):3833-3841. doi: 10.1002/ehf2.14963. Epub 2024 Jul 17.
This study aimed to investigate the relationship between the triglyceride glucose (TyG) index and all-cause mortality in patients with heart failure (HF).
A total of 1274 patients with HF diagnosed at Hebei General Hospital were enrolled in this study. The patients were divided into four groups by quartiles based on the TyG index. The endpoint was all-cause mortality during the follow-up period. The median follow-up period was 1079 days, with a total of 543 (42.7%) patients experiencing all-cause mortality. The survival curves showed no significant difference in endpoint events among the four groups (log-rank P = 0.329). The adjusted survival curves revealed that after adjusting for the variables in Model 3, the group with a higher TyG index exhibited a higher risk of death (log-rank P < 0.001). The multivariate-adjusted Cox proportional hazard models revealed a positive correlation between the TyG index and all-cause mortality. After complete adjustment, patients with the highest TyG index exhibited a higher risk of all-cause mortality than those in the lowest quartile [hazard ratio (HR) = 1.6, 95% confidence interval (CI): 1.22-2.09; P = 0.001]. Restricted cubic spline analysis showed that the risk of all-cause mortality increased linearly with the TyG index (P for non-linear = 0.207). Exploratory subgroup analyses revealed that, as a continuous variable, the TyG index was significantly associated with all-cause mortality in female patients (HR = 1.31, 95% CI: 1.08-1.58, P = 0.029) and older patients (HR = 1.25, 95% CI: 1.1-1.43, P = 0.027).
The TyG index was positively associated with increased all-cause mortality in hospitalized patients with HF. Subgroup analyses indicated that the TyG index was strongly associated with all-cause mortality in older and female patients.
本研究旨在探讨心力衰竭（HF）患者的甘油三酯葡萄糖（TyG）指数与全因死亡率之间的关系。
本研究纳入了河北医科大学第一医院诊断为HF的1274例患者。根据TyG指数将患者分为四组。终点为随访期间的全因死亡率。中位随访期为1079天，共有543例（42.7%）患者发生全因死亡。生存曲线显示四组终点事件无显著差异（对数秩检验P = 0.329）。调整后的生存曲线显示，在对模型3中的变量进行调整后，TyG指数较高的组死亡风险更高（对数秩检验P < 0.001）。多因素调整的Cox比例风险模型显示TyG指数与全因死亡率呈正相关。完全调整后，TyG指数最高的患者全因死亡风险高于最低四分位数组[风险比（HR）= 1.6，95%置信区间（CI）：1.22 - 2.09；P = 0.001]。限制立方样条分析显示，全因死亡风险随TyG指数呈线性增加（非线性P = 0.207）。探索性亚组分析显示，作为连续变量，TyG指数与女性患者（HR = 1.31，95%CI：1.08 - 1.58，P = 0.029）和老年患者（HR = 1.25，95%CI：1.1 - 1.43，P = 0.027）的全因死亡率显著相关。
TyG指数与住院HF患者全因死亡率增加呈正相关。亚组分析表明，TyG指数与老年和女性患者的全因死亡率密切相关。
