甘油三酯-葡萄糖指数及甘油三酯-葡萄糖/体重指数与中国百岁老人全因死亡率的关联

Associations of the triglyceride-glucose index and triglyceride-glucose/body mass index with all-cause mortality in Chinese centenarians.

作者信息

Yan Shiju, Dong Wenjing, Niu Yue, Song Lingyun, Pang Ping, Sun Di, Zhang Yue, Wang Wei, Hu Hongyan, Jin Xinye, Zhang Jie, Luo Qing, Sun Ding, Li Hao, Zhang Zehao, Qu Zeyu, Zhu Qiao, Chen Yujian, Ning Chaoxue, Fu Shihui, Yang Shanshan, Wang Shengshu, He Yao, Wang Bin, Zhao Yali, Yang Guoqing, Chen Xiangmei, Liu Miao, Chen Yizhi

机构信息

Department of Orthopedics, Hainan Hospital of Chinese PLA General Hospital, Hainan, Sanya, 572013, China.

Department of Endocrinology, Hainan Hospital of Chinese PLA General Hospital, Hainan, Sanya, 572013, China.

出版信息

BMC Geriatr. 2025 Apr 23;25(1):266. doi: 10.1186/s12877-025-05894-w.

DOI:10.1186/s12877-025-05894-w

PMID:40269748

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12016446/

Abstract

BACKGROUND

The triglyceride-glucose (TyG) index and triglyceride-glucose/body mass index (TyG-BMI) have been shown to be associated with cardiovascular and cerebrovascular disorders and the risk of death. The aim of this study was to explore the relationships of the TyG index and TyG-BMI with all-cause mortality among Chinese centenarians.

METHODS

Data from the China Hainan Centenarian Cohort Study (CHCCS) were analyzed. Eligible centenarians were divided into quartiles on the basis of their TyG and TyG-BMI indices. Kaplan‒Meier analysis was used to compare survival times across groups. The associations of the TyG index and TyG-BMI with all-cause mortality were investigated using restricted cubic splines (RCSs) and Cox proportional hazards regression models. Moreover, the concordance of the associations of the TyG index and TyG-BMI with all-cause mortality in different subgroups was further explored by subgroup analysis.

RESULTS

A total of 921 centenarian participants were included in this study. During a median follow-up of 29.70 months, 852 (92.5%) centenarians died. The results of the RCS analysis demonstrated that the TyG index and TyG-BMI were both linearly and negatively associated with all-cause mortality. Compared with that for the highest the TyG index and TyG-BMI quartile groups, higher risks of death were found for the lowest quartile groups (TyG Q1 vs. Q4, HR 1.27, 95% CI 1.03-1.56, P = 0.024; TyG-BMI Q1 vs. Q4, HR 1.60, 95% CI 1.30-1.96, P < 0.001). Centenarians with lower TyG index and TyG-BMI values had significantly greater mortality risks according to the Kaplan‒Meier analysis (log-rank P = 0.020, log-rank P < 0.001, respectively). Subgroup analysis demonstrated that blood pressure could influence the linear negative correlation between the TyG-BMI and all-cause mortality.

CONCLUSION

Both lower TyG and TyG-BMI indices were significantly associated with higher all-cause mortality in Chinese centenarians, whereas the TyG-BMI was superior to the TyG index in predicting the mortality risk of centenarians.

摘要

背景

甘油三酯-葡萄糖（TyG）指数和甘油三酯-葡萄糖/体重指数（TyG-BMI）已被证明与心血管和脑血管疾病以及死亡风险相关。本研究旨在探讨TyG指数和TyG-BMI与中国百岁老人全因死亡率之间的关系。

方法

分析了来自中国海南百岁老人队列研究（CHCCS）的数据。符合条件的百岁老人根据其TyG和TyG-BMI指数分为四分位数。采用Kaplan-Meier分析比较各组的生存时间。使用受限立方样条（RCS）和Cox比例风险回归模型研究TyG指数和TyG-BMI与全因死亡率的关联。此外，通过亚组分析进一步探讨TyG指数和TyG-BMI与不同亚组全因死亡率关联的一致性。

结果

本研究共纳入921名百岁老人参与者。在中位随访29.70个月期间，852名（92.5%）百岁老人死亡。RCS分析结果表明，TyG指数和TyG-BMI均与全因死亡率呈线性负相关。与TyG指数和TyG-BMI最高四分位数组相比，最低四分位数组的死亡风险更高（TyG Q1与Q4相比，HR 1.27，95%CI 1.03-1.56，P = 0.024；TyG-BMI Q1与Q4相比，HR 1.60，95%CI 1.30-1.96，P < 0.001）。根据Kaplan-Meier分析，TyG指数和TyG-BMI值较低的百岁老人的死亡风险显著更高（对数秩检验P = 0.020，对数秩检验P < 0.001）。亚组分析表明，血压可影响TyG-BMI与全因死亡率之间的线性负相关。