Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russian Federation.
Postepy Biochem. 2024 May 23;70(1):22-32. doi: 10.18388/pb.2021_512.
The review analyzes the role of physicochemical processes in the formation of the function-dependent architecture of the cell nucleus, built on the platform of a folded genome. The main attention is paid to various forms of the phase separation process, primarily the processes of liquid-liquid phase separation and polymer-polymer phase separation. The role of these processes in the formation of chromatin compartments and maintenance of three-dimensional genome architecture is discussed in detail. The relationship between genome activity and the creation of functional compartments in the cell nucleus is also analyzed.
该综述分析了物理化学过程在折叠基因组平台上形成依赖于功能的细胞核结构中的作用。主要关注各种形式的相分离过程，主要是液-液相分离和聚合物-聚合物相分离过程。详细讨论了这些过程在染色质隔室形成和维持三维基因组结构中的作用。还分析了基因组活性与细胞核中功能性隔室形成之间的关系。
