Akopov S, Darbinian V, Grigorian G, Kosyan A, Gabrielian E
Department of Pharmacology, Yerevan Medical Institute, Armenia.
Eur Neurol. 1993;33(3):252-5. doi: 10.1159/000116948.
Blood and plasma from 193 patients at risk of cerebrovascular disorders and 87 patients with brain infarction were tested to study prostacyclin (PGI2) degradation. It has been reported that patients at risk for cerebrovascular disorders and especially with brain infarction have an enhanced velocity of PGI2 degradation. The increase in velocity was more marked in blood than in plasma. A direct relation between this enhancement and the manifestation of intravascular platelet activation was observed. These data suggest that elevated PGI2 degradation might be a risk factor for thromboembolic events in patients with cerebrovascular disorders.
对193名有脑血管疾病风险的患者以及87名脑梗死患者的血液和血浆进行检测，以研究前列环素（PGI2）的降解情况。据报道，有脑血管疾病风险尤其是患有脑梗死的患者，其PGI2降解速度加快。血液中速度的增加比血浆中更为明显。观察到这种增强与血管内血小板激活的表现之间存在直接关系。这些数据表明，PGI2降解升高可能是脑血管疾病患者发生血栓栓塞事件的一个风险因素。
