Department of Inorganic and Organic Chemistry, University of Barcelona, Calle Marti i Fraquès 1-11, 08028 Barcelona, Spain.
Institute for Bioengineering of Catalonia (IBEC), Calle Baldiri Reixac 10-12, 08028 Barcelona, Spain.
J Mater Chem B. 2024 Jul 31;12(30):7292-7297. doi: 10.1039/d4tb00862f.
Chirality is one of the hallmarks of biomolecules. Herein, we utilize heparin, a chiral biomolecule and potent drug, to induce chiral organization into the assembly of an achiral molecule. Polyanionic heparin binds with a dicationic perylenediimide derivative to induce supramolecular helical organization in aqueous medium as well as in a highly competitive cell culture medium.
手性是生物分子的特征之一。在这里，我们利用肝素——一种手性生物分子和有效的药物——诱导手性分子的组装。聚阴离子肝素与二价苝二酰亚胺衍生物结合，在水介质以及高度竞争的细胞培养基中诱导超分子螺旋组织。
