尺寸至关重要：一种用于体内基因组编辑的新型紧凑型Cas12a变体
When size matters: A novel compact Cas12a variant for in vivo genome editing.
作者信息
Bubeck Felix, Grimm Dirk
机构信息
Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, Heidelberg University, Heidelberg, Germany.
BioQuant, BQ0030, Heidelberg University, Heidelberg, Germany.
出版信息
PLoS Biol. 2024 Jul 17;22(7):e3002637. doi: 10.1371/journal.pbio.3002637. eCollection 2024 Jul.
Abstract
A new study characterizes and improves a novel small Cas12a variant before adapting it for in vivo genome editing by delivery via adeno-associated virus (AAV) vectors, showcasing the potential of small CRISPR systems and their compatibility with viral vectors.
摘要
一项新研究对一种新型小Cas12a变体进行了表征和改进，然后通过腺相关病毒（AAV）载体递送使其适用于体内基因组编辑，展示了小型CRISPR系统的潜力及其与病毒载体的兼容性。
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