Siddiqui Muhammad Tayyab, Shaukat Fatima, Khan Muhammad Rizwan, Zahid Nida, Arbani Shumaila
Department of Surgical Oncology, Dow University Hospital (DUHS) Karachi, Pakistan.
Department of Radiation Oncology, Cyberknife and Tomotherpay Centre, Jinnah Post-Graduate Medical Center, Karachi, Pakistan.
J Surg Res. 2024 Sep;301:336-344. doi: 10.1016/j.jss.2024.06.015. Epub 2024 Jul 16.
Colorectal cancer (CRC) and its therapy profoundly affect the quality of life (QoL) of patients. The emotional distress: anxiety and depression also negatively affect wellbeing of these patients. This study aims to evaluate the QoL, anxiety, and depression in CRC patients and their association with clinic-pathological features at a tertiary care hospital in Karachi Pakistan, a low middle income country.
An analytical cross-sectional study was conducted on adult CRC patients. QoL was assessed using the European Organization for Research and Treatment of Cancer QoL questionnaire C30 and CR29. Hospital Anxiety and Depression Score was used to evaluate the anxiety and depression. Analyses were performed using STATA version 12, including multivariable linear and multivariate analysis of variance. A P value of < 0.05 was considered as significant.
A total of 127 CRC patients with mean age of 53 ± 15 y participated. Mean global QoL score was 69.08 ± 1.78. Among symptoms scales: stoma care problem and among functional scales: sexual interest (women > men) were the most significantly affected aspect. Anxiety and depression were seen in 26 (20.9%) and 24 (18.9%) patients, respectively. Lower global QoL was significantly associated with depression (-25.33 [95% confidence interval: -34.4, -16.23]), on adjuvant treatment (-15.14 [-21.84, -8.44]), and neoadjuvant treatment (-11.75 [-19.84, -3.65]).
This is the first study assessing the QoL in CRC patients in Pakistan. Depression was found to be significantly associated with poor QoL. Numerous factors correlated with low QoL scores indicating the need to develop local guidelines to address psychological distress in our patients.
结直肠癌（CRC）及其治疗对患者的生活质量（QoL）有深远影响。情绪困扰，如焦虑和抑郁，也会对这些患者的幸福感产生负面影响。本研究旨在评估巴基斯坦卡拉奇一家三级护理医院中CRC患者的生活质量、焦虑和抑郁情况，以及它们与临床病理特征的关联，巴基斯坦是一个中低收入国家。
对成年CRC患者进行了一项分析性横断面研究。使用欧洲癌症研究与治疗组织生活质量问卷C30和CR29评估生活质量。采用医院焦虑和抑郁量表评估焦虑和抑郁情况。使用STATA 12版进行分析，包括多变量线性分析和多变量方差分析。P值<0.05被认为具有统计学意义。
共有127例CRC患者参与，平均年龄为53±15岁。全球生活质量平均得分为69.08±1.78。在症状量表中，造口护理问题最为突出；在功能量表中，性兴趣（女性>男性）受影响最为显著。分别有26例（20.9%）和24例（18.9%）患者存在焦虑和抑郁。较低的全球生活质量与抑郁（-25.33 [95%置信区间：-34.4，-16.23]）、辅助治疗（-15.14 [-21.84，-8.44]）和新辅助治疗（-11.75 [-19.84，-3.65]）显著相关。
这是巴基斯坦第一项评估CRC患者生活质量的研究。发现抑郁与生活质量差显著相关。许多因素与低生活质量得分相关，表明需要制定当地指南以解决患者的心理困扰。
