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农业、健康和兽医害虫节肢动物中的基因编辑:最新进展。

Gene editing in agricultural, health, and veterinary pest arthropods: recent advances.

机构信息

Department of Agriculture, Veterinary, and Rangeland Sciences, University of Nevada, Reno, USA.

Department of Biochemistry and Molecular Biology, University of Nevada, Reno, USA.

出版信息

Curr Opin Insect Sci. 2024 Oct;65:101235. doi: 10.1016/j.cois.2024.101235. Epub 2024 Jul 15.

Abstract

Pest arthropods cause significant crop damage or are vectors of pathogens for both plants and animals. The current standard of pest management prevents against crop losses and protects human and animal health, but shortcomings exist, such as insecticide resistance and environmental damage to nontarget organisms. New management methods are therefore needed. The development of new tools, such as site-specific gene editing, has accelerated the study of gene function and phenotype in nonmodel arthropod species and may enable the development of new strategies for pathogen and arthropod control. Here, the most recent developments in gene editing in arthropod pests are briefly reviewed. Additionally, technological advances that could be applicable to new species or enhance the success rates of gene editing in species with already established protocols are highlighted.

摘要

有害节肢动物会对作物造成严重损害,或者是动植物病原体的传播媒介。目前的有害生物管理标准可以防止作物损失,保护人类和动物健康,但也存在一些缺点,例如杀虫剂抗性和对非目标生物的环境破坏。因此,需要新的管理方法。新工具的开发,如定点基因编辑,加速了非模式节肢动物物种中基因功能和表型的研究,并可能为病原体和节肢动物的控制开发新策略。本文简要回顾了节肢动物害虫基因编辑的最新进展。此外,还强调了一些技术进步,这些进步可能适用于新物种,或者提高已经建立了相关方案的物种的基因编辑成功率。

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