Shkutin A E
Arkh Patol. 1985;47(6):80-4.
The death of the alveolar macrophage stimulating the activation of fibroblast in pneumoconiosis is not a single trigger mechanism of pneumofibrosis in anthracosis. Alteration of the microcirculatory bed and lung aerohematic barrier plays an essential pathogenetic role in coal pneumoconiosis. Polycarbonic acids which are formed in the organism from coal as a result of its oxidative-hydrolytic degradation are the cause of the damage and loss of the structural components of the aerohematic barrier.
尘肺中肺泡巨噬细胞死亡刺激成纤维细胞活化并非煤工尘肺肺纤维化的单一触发机制。微循环床和肺气血屏障的改变在煤工尘肺发病机制中起重要作用。煤在机体中经氧化水解降解形成的多元碳酸是气血屏障结构成分损伤和丧失的原因。
