Bickel M, Cimasoni G, Andersen E
Arch Oral Biol. 1985;30(8):599-602. doi: 10.1016/0003-9969(85)90079-2.
Gingival fluid was collected with glass capillaries tubing from the upper premolar area in a group of 7 volunteers, after allowing dental plaque to accumulate for 12-36 h, and in a group of patients with gingivitis. Whereas no fluid could be collected in the absence of plaque, increasing amounts were recovered during plaque accumulation, in the absence of clinical signs of gingival inflammation. The ratios of albumin concentrations in gingival fluid and plasma also increased significantly with increasing time of plaque accumulation. These fluid:plasma ratios of albumin concentrations were significantly lower than the ratios found for the inflamed sites in the second group of patients. These results support the hypothesis that, in an early inflammatory response, the fluid is not a typical inflammatory exudate and is probably modulated by an osmotic gradient.
在7名志愿者的上颌前磨牙区域，待牙菌斑积聚12 - 36小时后，用玻璃毛细管收集龈沟液；同时也收集了一组牙龈炎患者的龈沟液。在没有牙菌斑的情况下无法收集到龈沟液，而在没有牙龈炎症临床体征的情况下，随着牙菌斑的积聚，收集到的龈沟液量不断增加。龈沟液和血浆中白蛋白浓度的比值也随着牙菌斑积聚时间的增加而显著升高。这些白蛋白浓度的龈沟液与血浆比值显著低于第二组患者炎症部位的比值。这些结果支持了这样一种假说，即在早期炎症反应中，龈沟液不是典型的炎性渗出液，可能是由渗透梯度调节的。
