Kinane D F, Winstanley F P, Adonogianaki E, Moughal N A
Department of Oral Medicine and Pathology, University of Glasgow Dental School, U.K.
Arch Oral Biol. 1992 Feb;37(2):153-6. doi: 10.1016/0003-9969(92)90011-v.
The cytokine IL-1 was demonstrated in crevicular fluid during a 14- and 21-day experimental gingivitis in healthy human volunteers. A sensitive and specific bioassay allowed detection of biologically active IL-1 at levels ranging from 0.18 ng/microliters at baseline to 1.70 ng/microliters in inflamed gingiva. Levels of IL-1 increased rapidly with plaque accumulation and in advance of the subsequent gingival inflammation, peaking within 7 days of the start of gingivitis. As changes in IL-1 were detected before clinically recognizable gingival changes, IL-1 may have potential as an early marker of gingival inflammatory changes.
在健康人类志愿者的14天和21天实验性牙龈炎期间，龈沟液中检测到细胞因子白细胞介素-1（IL-1）。一种灵敏且特异的生物测定法能够检测到生物活性IL-1，其水平范围从基线时的0.18纳克/微升至炎症牙龈中的1.70纳克/微升。IL-1水平随着菌斑积聚而迅速升高，且先于随后的牙龈炎症出现，在牙龈炎开始后的7天内达到峰值。由于在临床上可识别的牙龈变化之前就检测到了IL-1的变化，因此IL-1可能有潜力作为牙龈炎症变化的早期标志物。
