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Rewiring the brain: Inflammation's impact on glutamate and neural networks in depression.

作者信息

Haroon Ebrahim, Miller Andrew H

机构信息

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Ste 6003, Atlanta, GA, 30322, USA.

出版信息

Neuropsychopharmacology. 2024 Nov;50(1):312-313. doi: 10.1038/s41386-024-01921-3.

DOI:10.1038/s41386-024-01921-3
PMID:39020141
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11525645/
Abstract
摘要

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本文引用的文献

1
Kynurenines increase MRS metabolites in basal ganglia and decrease resting-state connectivity in frontostriatal reward circuitry in depression.犬尿氨酸增加了基底神经节中的 MRS 代谢物，并降低了抑郁症患者额纹状体奖励回路中的静息状态连接。
Transl Psychiatry. 2021 Sep 4;11(1):456. doi: 10.1038/s41398-021-01587-1.
2
Increased inflammation and brain glutamate define a subtype of depression with decreased regional homogeneity, impaired network integrity, and anhedonia.炎症增加和大脑谷氨酸水平升高定义了一种具有局部一致性降低、网络完整性受损和快感缺失的抑郁症亚型。
Transl Psychiatry. 2018 Sep 10;8(1):189. doi: 10.1038/s41398-018-0241-4.
3
Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders.炎症、谷氨酸和神经胶质细胞：情绪障碍中的三重麻烦
Neuropsychopharmacology. 2017 Jan;42(1):193-215. doi: 10.1038/npp.2016.199. Epub 2016 Sep 15.
4
Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression.概念趋同：在重度抑郁症患者中，炎症增加与基底节谷氨酸增加有关。
Mol Psychiatry. 2016 Oct;21(10):1351-7. doi: 10.1038/mp.2015.206. Epub 2016 Jan 12.
5
Age-related increases in basal ganglia glutamate are associated with TNF, reduced motivation and decreased psychomotor speed during IFN-alpha treatment: Preliminary findings.基底神经节谷氨酸随年龄增长而增加与肿瘤坏死因子、干扰素-α治疗期间动机降低和精神运动速度减慢有关：初步研究结果。
Brain Behav Immun. 2015 May;46:17-22. doi: 10.1016/j.bbi.2014.12.004. Epub 2014 Dec 9.
6
IFN-alpha-induced cortical and subcortical glutamate changes assessed by magnetic resonance spectroscopy.通过磁共振波谱评估干扰素-α诱导的皮质和皮质下谷氨酸变化。
Neuropsychopharmacology. 2014 Jun;39(7):1777-85. doi: 10.1038/npp.2014.25. Epub 2014 Jan 31.