Bian Hupo, Zhu Shaoqi, Xing Wenjian, Qi Luying, Xue Jingnan, Peng Xiuhua, Jin Zanhui, Zhao Hongxing
Department of Radiology, The First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, People's Republic of China.
Department of Endocrinology, The First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, People's Republic of China.
Int J Chron Obstruct Pulmon Dis. 2025 Jan 7;20:23-41. doi: 10.2147/COPD.S495326. eCollection 2025.
There is increasing evidence that chronic obstructive pulmonary disease (COPD) is associated with coronary heart disease (CHD). In this study, we provide valuable insights in the field by examining the evolution of the relationship between COPD and CHD over the past 20 years.
A comprehensive computer search was conducted in the Web of Science (WOS) core dataset, covering literature on COPD combined with CHD from January 1, 2005, to August 20, 2024. Visual analyses were performed using VOSviewer, CiteSpace, and Bibliometrix to assess countries, institutions, the centrality of institutional intermediaries, authorship patterns, including co-cited authors and references, and keywords; Excel (version 2021) software was utilized for generating relevant descriptive analysis tables.
A total of 2420 publications sourced from WOS were included in this study. Since 2005, there has been a continuous increase in the literature about COPD combined with CHD; polynomial fitting yielded an value of 0.7758. The volume of literature in this domain is projected to continue growing steadily. The United States emerged as the leading country by publication count; Lin Cheng-li ranked first among authors, while China Medical University topped institutional contributions. Notably, Sin dd, Mannino dm, and Helvaci Mr were identified as the top three authors based on citation frequency. The Journal of Vascular Surgery recorded the highest number of publications, whereas The Lancet was recognized as the most influential among the top ten co-cited journals. The most frequently cited reference pertains to systemic inflammation's role in increasing cardiovascular risk among patients with COPD. Through keyword clustering analysis, we categorized all keywords into three distinct groups: management strategies for COPD and CHD; diseases associated with both conditions; and epidemiological characteristics concerning their burden-current hotspots include multimorbidity factors such as hypertension and obesity alongside outcomes like diagnosis during COVID-19 pandemic implications within societal contexts are highlighted here too.
Presently focused research on COPD coupled with CHD primarily revolves around five key areas: pathogenesis exploration, early diagnostic techniques, COVID-19 infection, dynamics intervention, methodologies, and treatment protocol development efforts. To improve the early detection rate of COPD complicated with CHD, the main development direction in the future is to extract computed tomography (CT) features using imaging omics and establish an early prediction model. The results of this study will provide new ideas and directions for subsequent related research.
越来越多的证据表明慢性阻塞性肺疾病（COPD）与冠心病（CHD）有关。在本研究中，我们通过考察过去20年中COPD与CHD之间关系的演变，为该领域提供了有价值的见解。
在科学网（WOS）核心数据集中进行全面的计算机检索，涵盖2005年1月1日至2024年8月20日有关COPD合并CHD的文献。使用VOSviewer、CiteSpace和Bibliometrix进行可视化分析，以评估国家、机构、机构中介的中心性、作者模式（包括共同被引作者和参考文献）以及关键词；利用Excel（2021版）软件生成相关描述性分析表。
本研究共纳入来自WOS的2420篇出版物。自2005年以来，关于COPD合并CHD的文献持续增加；多项式拟合得到的值为0.7758。该领域的文献量预计将继续稳步增长。按发表数量计算，美国成为领先国家；程立林在作者中排名第一，而中国医科大学在机构贡献方面位居榜首。值得注意的是，根据被引频次，Sin dd、Mannino dm和Helvaci Mr被确定为排名前三的作者。《血管外科杂志》发表的文章数量最多，而《柳叶刀》在十大共同被引期刊中被认为最具影响力。最常被引用的参考文献涉及全身炎症在增加COPD患者心血管风险中的作用。通过关键词聚类分析，我们将所有关键词分为三个不同的组：COPD和CHD的管理策略；与这两种疾病相关的疾病；以及关于其负担的流行病学特征——当前的热点包括高血压和肥胖等共病因素以及COVID-19大流行期间的诊断等结果，社会背景下的影响也在此突出显示。
目前关于COPD合并CHD的重点研究主要围绕五个关键领域：发病机制探索、早期诊断技术、COVID-19感染、动态干预、方法学以及治疗方案制定。为提高COPD合并CHD的早期检出率，未来的主要发展方向是利用影像组学提取计算机断层扫描（CT）特征并建立早期预测模型。本研究结果将为后续相关研究提供新思路和方向。
